Journal of Zhejiang University SCIENCE B 2026 Vol.27 No.4 P.343-358

http://doi.org/10.1631/jzus.B2400579


Neuroscientific therapies for subjective tinnitus


Author(s):  Peng LIU, Xinmiao XUE, Zhixin ZHANG, Hanwen ZHOU, Cong XU, Lijun ZHANG, Zhen LI, Yongqing ZHOU, Shanwei SONG, Yameng TIAN, Fangyuan WANG, Xiaoming LI, Shiming YANG

Affiliation(s):  1. Department of Otolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang 050011, China more

Corresponding email(s):   fangyuanwang05@163.com, xmlmo@126.com, shm_yang@163.com

Key Words:  Tinnitus, Neuromodulation, Magnetic stimulation, Electrical stimulation, Light stimulation


Peng LIU, Xinmiao XUE, Zhixin ZHANG, Hanwen ZHOU, Cong XU, Lijun ZHANG, Zhen LI, Yongqing ZHOU, Shanwei SONG, Yameng TIAN, Fangyuan WANG, Xiaoming LI, Shiming YANG. Neuroscientific therapies for subjective tinnitus[J]. Journal of Zhejiang University Science B, 2026, 27(4): 343-358.

@article{title="Neuroscientific therapies for subjective tinnitus",
author="Peng LIU, Xinmiao XUE, Zhixin ZHANG, Hanwen ZHOU, Cong XU, Lijun ZHANG, Zhen LI, Yongqing ZHOU, Shanwei SONG, Yameng TIAN, Fangyuan WANG, Xiaoming LI, Shiming YANG",
journal="Journal of Zhejiang University Science B",
volume="27",
number="4",
pages="343-358",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400579"
}

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%T Neuroscientific therapies for subjective tinnitus
%A Peng LIU
%A Xinmiao XUE
%A Zhixin ZHANG
%A Hanwen ZHOU
%A Cong XU
%A Lijun ZHANG
%A Zhen LI
%A Yongqing ZHOU
%A Shanwei SONG
%A Yameng TIAN
%A Fangyuan WANG
%A Xiaoming LI
%A Shiming YANG
%J Journal of Zhejiang University SCIENCE B
%V 27
%N 4
%P 343-358
%@ 1673-1581
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400579

TY - JOUR
T1 - Neuroscientific therapies for subjective tinnitus
A1 - Peng LIU
A1 - Xinmiao XUE
A1 - Zhixin ZHANG
A1 - Hanwen ZHOU
A1 - Cong XU
A1 - Lijun ZHANG
A1 - Zhen LI
A1 - Yongqing ZHOU
A1 - Shanwei SONG
A1 - Yameng TIAN
A1 - Fangyuan WANG
A1 - Xiaoming LI
A1 - Shiming YANG
J0 - Journal of Zhejiang University Science B
VL - 27
IS - 4
SP - 343
EP - 358
%@ 1673-1581
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400579


Abstract: 
tinnitus, a prevalent auditory symptom, can significantly impair quality of life, yet no definitive pharmacological interventions exist despite extensive ongoing research into its pathophysiology and treatments. The advent of biomedical engineering has introduced neuromodulation as a pivotal therapeutic approach alongside conventional strategies such as pharmacotherapy and surgery. Through the deployment of invasive and non-invasive techniques, using various modalities including magnetic, electronic, and optical means, neuromodulation aims to regulate neural functions. This has not only led to the refinement of fundamental theories but has also enhanced the optimization of clinical applications. As an emerging and promising intervention, neuromodulation enriches the toolkit available for basic neuroscience inquiry and broadens the spectrum of clinical therapies for conditions affecting the central nervous system, including tinnitus. In this paper, we succinctly review the current understanding of tinnitus mechanisms, discuss the features of diverse neuromodulation technologies, explore their application in tinnitus management, and contemplate prospects for their development in treating tinnitus.

主观性耳鸣的神经调控治疗

刘鹏1,薛鑫淼2,张志鑫2,周函汶2,徐丛1,张丽君1,李震1,周永青1,宋钐炜3,田雅萌1,王方园2,李晓明1,杨仕明2
1白求恩国际和平医院耳鼻喉头颈外科,中国石家庄,050011
2中国人民解放军总医院耳鼻咽喉头颈外科,耳鼻咽喉头颈外科研究所,中国北京,100853
3天津理工大学化学化工学院,中国天津,300380
摘要:耳鸣作为一种常见的听觉障碍,显著影响患者的生活质量。尽管其病理生理机制和治疗策略已被广泛研究,目前仍缺乏明确有效的治疗药物。随着生物医学工程的发展,神经调控技术已成为与药物和手术等传统策略并重的治疗方法。该技术通过侵入性或非侵入性方式,利用磁、电和光等多种物理刺激,实现对神经功能的调节。神经调控技术不仅推动了基本理论的进展,也促进了临床应用的优化。作为一种新兴且前景广阔的治疗手段,神经调控丰富了基础神经科学的研究工具,并拓宽了中枢神经系统疾病(包括耳鸣)的临床治疗途径。本文简要回顾了耳鸣的发病机制,讨论了不同神经调控技术的特点及其在耳鸣治疗方面的应用现状,并对未来的发展前景进行展望。

关键词:耳鸣;神经调控;磁刺激;电刺激;光刺激

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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On-line Access: 2026-04-24

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 ORCID:

Peng LIU

https://orcid.org/0000-0002-2797-6949

Xinmiao XUE

https://orcid.org/0000-0002-0005-4207

Zhixin ZHANG

https://orcid.org/0009-0002-2622-3301

Fangyuan WANG

https://orcid.org/0000-0002-9880-3930

Xiaoming LI

https://orcid.org/0000-0002-0931-727X

Shiming YANG

https://orcid.org/0000-0001-5711-5616

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