CLC number: R725.4
On-line Access: 2024-08-27
Received: 2023-10-17
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GONG Fang-qi, KANG Man-li, XIA Cheng-sen. EFFECT OF NEBULIZED NITROGLYCERIN ON CHILDREN WITH VENTRICULAR SEPTAL DEFECT AND PULMONARY HYPERTENSION[J]. Journal of Zhejiang University Science A, 2000, 1(2): 218-221.
@article{title="EFFECT OF NEBULIZED NITROGLYCERIN ON CHILDREN WITH VENTRICULAR SEPTAL DEFECT AND PULMONARY HYPERTENSION",
author="GONG Fang-qi, KANG Man-li, XIA Cheng-sen",
journal="Journal of Zhejiang University Science A",
volume="1",
number="2",
pages="218-221",
year="2000",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2000.0218"
}
%0 Journal Article
%T EFFECT OF NEBULIZED NITROGLYCERIN ON CHILDREN WITH VENTRICULAR SEPTAL DEFECT AND PULMONARY HYPERTENSION
%A GONG Fang-qi
%A KANG Man-li
%A XIA Cheng-sen
%J Journal of Zhejiang University SCIENCE A
%V 1
%N 2
%P 218-221
%@ 1869-1951
%D 2000
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2000.0218
TY - JOUR
T1 - EFFECT OF NEBULIZED NITROGLYCERIN ON CHILDREN WITH VENTRICULAR SEPTAL DEFECT AND PULMONARY HYPERTENSION
A1 - GONG Fang-qi
A1 - KANG Man-li
A1 - XIA Cheng-sen
J0 - Journal of Zhejiang University Science A
VL - 1
IS - 2
SP - 218
EP - 221
%@ 1869-1951
Y1 - 2000
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2000.0218
Abstract: In order to find a safe, simple, effective and selective pulmonary vasodilator, we tested the effectiveness and safety of inhalation of nebulized nitroglycerin (Neb-NTG) by children with ventricular septal defect and pulmonary hypertension (VSD-PH). Twenty μg/kg Neb-NTG was inhaled by seven children with VSD-PH using face mask during cardiac catheterization. The pulmonary artery pressure (PAP), systemic arterial pressure (SAP) and methemoglobin (MetHb) concentration were measured before and after inhalation of Neb-NTG. After inhalation of Neb-NTG, the PAP and pulmonary-to-systemic pressure ratio (Pp/Ps) decreased significantly; There was no significant decrease in SAP. The systolic and diastolic PAP decreased respectively 13±4% and 9±7% in 5 min, 21±3% and 13±17% in 10 min, 24±3% and 16±19% in 15 min. The Pp/Ps decreased 12±4% in 5 min, 21±9% in 10 min and 24±6% in 15 min. There was no significant increase in the MetHb level after inhalation of 20 μg/kg of Neb-NTG. The MetHb level was below 1.5%. Neb-NTG is a safe, simple, effective and selective pulmonary vasodilator.
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