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Received: 2003-04-18

Revision Accepted: 2003-07-21

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Journal of Zhejiang University SCIENCE A 2003 Vol.4 No.6 P.749-752

http://doi.org/10.1631/jzus.2003.0749


Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction


Author(s):  LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping

Affiliation(s):  Department of Neurology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   lobenyan@263.net

Key Words:  Cerebral infarction, Atherosclerotic, Genetics, ApoE allele, Single nucleotide polymorphism


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LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping. Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction[J]. Journal of Zhejiang University Science A, 2003, 4(6): 749-752.

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author="LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2003.0749"
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%A CHEN Zhi
%A CHEN Feng
%A LI Xia
%A PAN Xiao-ping
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%P 749-752
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2003.0749

TY - JOUR
T1 - Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction
A1 - LUO Ben-yan
A1 - CHEN Zhi
A1 - CHEN Feng
A1 - LI Xia
A1 - PAN Xiao-ping
J0 - Journal of Zhejiang University Science A
VL - 4
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SP - 749
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2003.0749


Abstract: 
Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011). Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Kitagawa,K., Matsumoto, M., Kuwabara, K., Ohtsuki,T.and Hori,M., 2001.Delayed, but marked, expression of apolipoprotein E is involved in tissue clearance after cerebral infarction.J Cereb Blood Flow Metab, 21(10):1199-1207.

[2]MacLeod,M.J.,De Lange,R.P.,Breen,G.,Meiklejohn,D.,Lemmon,H.and Clair, D.S., 2001. Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population.Eur J Clin Invest, 31(7):570-573.

[3]Martin, E.R., Lai,E.H., Gilbert,J.R., Rogala,A.R., Afshari,A.J., Riley,J., Finch,K.L., Stevens,J.F., Livak,K.J.,Slotterbeck, B.D., Slifer,S.H., Warren,L.L., Conneally,P.M., Schmechel, D.E.,Purvis,I.,Pericak-Vance,M.A.,Roses,A.D.and Vance,J.M., 2000.SNPing away at complex disease: analysis of single-nucleotide polymorphisms around ApoE in Alzheimer disease.Am J Hum Genet, 67(2):383-394.

[4]McCarron,M.O., Delong,D.and Alberts,M.J., 1999.ApoE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis.Neurology, 53(6):1308-1311.

[5]McLean,J.W.,Elshourbagy,N.A.,Chang,D.J.,Mahley,R.W.and Taylor,J.M., 1984.Human apolipoprotein E mRNA.cDNA cloning and nucleotide sequencing of a new variant.J Biol Chem, 259(10):6498-6504.

[6]Siest,G., Pillot,T., Regis-Bailly, A., Leininger-Muller, B., Steinmetz,J., Galteau, M.M. and Visvikis, S., 1995.Apolipoprotein E: an important gene and protein to follow in laboratory medicine.Clin Chem, 418:1068-1086.

[7]Wang,D.G.,Fan,J.B.,Siao,C.J.,Berno,A.,Young,P.,Sapolsky,R.,Ghandour,G.,Perkins,N.,Winchester,E.,Spencer,J.,Kruglyak,L.,Stein,L.,Hsie,L.,Topaloglou,T.,Hubbell,E.,Robinson, E., Mittmann,M., Morris,M.S., Shen,N., Kilburn,D.,Rioux,J.,Nusbaum,C., Rozen,S., Hudson, T.J.and Lander, E.S., 1998.Large-Scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome.Science, 280(5366):1077-1082.

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