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Received: 2003-04-18
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Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction
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LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping. Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction[J]. Journal of Zhejiang University Science A, 2003, 4(6): 749-752.
@article{title="Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction",
author="LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping",
journal="Journal of Zhejiang University Science A",
volume="4",
number="6",
pages="749-752",
year="2003",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2003.0749"
}
%0 Journal Article
%T Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction
%A LUO Ben-yan
%A CHEN Zhi
%A CHEN Feng
%A LI Xia
%A PAN Xiao-ping
%J Journal of Zhejiang University SCIENCE A
%V 4
%N 6
%P 749-752
%@ 1869-1951
%D 2003
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2003.0749
TY - JOUR
T1 - Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction
A1 - LUO Ben-yan
A1 - CHEN Zhi
A1 - CHEN Feng
A1 - LI Xia
A1 - PAN Xiao-ping
J0 - Journal of Zhejiang University Science A
VL - 4
IS - 6
SP - 749
EP - 752
%@ 1869-1951
Y1 - 2003
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2003.0749
Abstract: Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011). Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
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