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Received: 2004-02-19

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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.12 P.1570-1576


Mutagenic effects of chromium trioxide on root tip cells of Vicia faba

Author(s):  QIAN Xiao-wei

Affiliation(s):  School of Life and Environmental Science, Wenzhou Normal College, Wenzhou 325003, China

Corresponding email(s):   qianxiaowei@126.com

Key Words:  Chromium trioxide (CrO3), Vicia faba, Mitotic index, Micronucleus rate, Rate of chromosome aberration

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QIAN Xiao-wei. Mutagenic effects of chromium trioxide on root tip cells of Vicia faba[J]. Journal of Zhejiang University Science A, 2004, 5(12): 1570-1576.

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%DOI 10.1631/jzus.2004.1570

T1 - Mutagenic effects of chromium trioxide on root tip cells of Vicia faba
A1 - QIAN Xiao-wei
J0 - Journal of Zhejiang University Science A
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1570

In this study on the mutagenic effects of different concentrations of chromium trioxide (CrO3) on vicia faba root tip, micronucleus assay and chromosome aberration assay were used to determine the mitotic indexes, micronucleus aberration rate and chromosome aberration rate of vicia fabaroot tip cells. The results showed that the effects of CrO3concentration on the mitotic indexes were complicated. CrO3 increases the micronucleus aberration rate of vicia faba root tip cells. It was found that within certain range of CrO3 concentration the micronucleus aberration rate increased systematically with increased concentration of CrO3, but that the micronucleus aberration rate decreased at higher level of CrO3 and that CrO3 also caused various types of chromosome aberration at a rate which increased systematically with increased concentration of CrO3. We concluded that CrO3 has significant mutagenic effect on vicia faba root tip cells.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Balansky, R.M., D’Agostini, F., Izzotti, A., 2000. Less than additive interaction between cigarette smoke and chromium (VI) in inducing clastogenic damage inrodents. Carcinogenesis, 21(9):1677-1682.

[2] Dai, M., Wu, Q., Zhou, X.Y., 1995. Application micronucleus technique of Vicia faba root tip cells to detect the mutagenesis of TNT and air in workshop. Carcinogenesis, Teratogenesis and Mutagenesis, 7(1):58-61 (in Chinese).

[3] Edward, J.D., Karen, E.W., 1994. Chromium (VI)-induced cytotoxicity and DNA damage occur via two distinct pathways: An oxidative pathway and direct chromium-DNA interaction. Met Ions Biol Med, (3):175-180.

[4] Li, H., 1997. Studies on abnormality of Wheat root tip cells induced by saturation solution of dichlorbenzol. J. Yuahou University (Natural Science), 14(1):36-42 (in Chinese).

[5] Li, N., Wang, Z.X., Yan, X.Q., 1995. The effect of Vitamin C and Vitamin E on mutagenesis induced by chromium F. J. of China Public Health, 14(3):158-159 (in Chinese).

[6] Li, H., Chen, C., Chen, Q.Y., 1997. The effect of chromium F on the sperm of male workers. Carcinogenesis, Teratogenesis and Mutagenesis, 9(1):11-13 (in Chinese).

[7] Liu, S.J., Gu, Z.W., Lu, Q.M., 1991. The identification of harm induced by low concentration of chromic acid mist. Chin. J. of Industrial Hygiene and Occupational Disease, 9(4):199-201 (in Chinese).

[8] Qian, X.W., 1998. Improvement on experiment method of micronucleus in root tip cells of Vicia faba. Journal of Wenzhou Normal College, 19(6):64-65 (in Chinese).

[9] Sjogren, B., Hansen, K.S., Kjuus, H., 1994. Exposure to stainless steel welding fumes and lung cancer: a meta-analysis [see comments]. Occupational ( Environmental Medicine, 51(5):335-336.

[10] Sorahan, T., Burges, D.C., Hamilton, L., 1998. Lung cancer mortality in nickel/chromium platers. Occupational ( Environmental Medicine, 1946-95, 55(4):236-242.

[11] Xing, H.T., Liang, W.F., 1997. On the effect Chinese Lacquer upon the cell division of root tip of Allium cepa. Acta Genetica Sinica, 24(1):50-53 (in Chinese).

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