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Received: 2005-05-31

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.12 P.1195-1199


Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE

Author(s):  CHEN Li-ying, YING Ke-jing, HONG Wu-jun, ZHOU Pan

Affiliation(s):  Department of Internal Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   cly0906@163.com, yingsrrsh@163.com

Key Words:  Low-molecular-weight-heparin (LMWH), Unfractionated heparin (UH), Venous thrombosis

CHEN Li-ying, YING Ke-jing, HONG Wu-jun, ZHOU Pan. Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE[J]. Journal of Zhejiang University Science B, 2005, 6(12): 1195-1199.

@article{title="Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE",
author="CHEN Li-ying, YING Ke-jing, HONG Wu-jun, ZHOU Pan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE
%A CHEN Li-ying
%A YING Ke-jing
%A HONG Wu-jun
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 12
%P 1195-1199
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B1195

T1 - Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE
A1 - CHEN Li-ying
A1 - YING Ke-jing
A1 - HONG Wu-jun
A1 - ZHOU Pan
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 12
SP - 1195
EP - 1199
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B1195

Objective: Acute pulmonary thromboembolism (PTE) is a serious high mortality pulmonary vascular disease whose effective treatment decreases morbidity and mortality. To determine if low-molecular-weight-heparin (LMWH) is clinically as efficient and safe as unfractionated heparin (UH) in patients with diagnosis of acute non-massive PTE, our study compares the efficacy, adverse effects and costs of LMWH and UH. Methods: One hundred and fourteen patients with non-massive acute PTE were randomly divided into LMWH (nadroparin calcium) and UH groups. Oxygenation index, D-dimer, fibrinogen (FG), lung ventilation/perfusion (V/Q) scan and computed tomography pulmonary angiography (CTPA) were observed before anticoagulation and on day 14 after anticoagulation. Results: In both groups, the ABG (arterial blood gas) analysis showed PaO2 and PaCO2 were elevated, P(A-a)O2 was decreased and oxygenation index (PaO2/FIO2) was elevated, D-dimer and fibrinogen were decreased, lung V/Q and CTPA showed embolized segments reduced (P<0.05). Hemorrhage and thrombocytopenia occurred in 3.5% of the LMWH group. Hemorrhage occurred in 5.3% and thrombocytopenia occurred in 7.0% of the UH group. The average cost in the LMWH group was RMB 1218.60 Yuan and RMB 1541.40 Yuan in the UH group. Conclusion: LMWH and UH are equally effective for treatment of non-massive acute PTE, but LMWH may have a lower prevalence of complications and is less expensive.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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