Full Text:   <3498>

CLC number: Q62; Q65

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 5

Clicked: 6321

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE A 2007 Vol.8 No.8 P.1237-1245

http://doi.org/10.1631/jzus.2007.A1237


Investigation of a spherical-section ultrasound phased array for hepatic ablation


Author(s):  ZHANG Chen-xi, CHEN Ya-zhu

Affiliation(s):  Institute of Biomedical Instrument, Shanghai Jiao Tong University, Shanghai 200030, China

Corresponding email(s):   chenxizhang@sjtu.edu.cn, yazhuchen@sjtu.edu.cn

Key Words:  Ultrasound phased-array, Blood perfusion, Temperature distribution, Numerical simulation


ZHANG Chen-xi, CHEN Ya-zhu. Investigation of a spherical-section ultrasound phased array for hepatic ablation[J]. Journal of Zhejiang University Science A, 2007, 8(8): 1237-1245.

@article{title="Investigation of a spherical-section ultrasound phased array for hepatic ablation",
author="ZHANG Chen-xi, CHEN Ya-zhu",
journal="Journal of Zhejiang University Science A",
volume="8",
number="8",
pages="1237-1245",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.A1237"
}

%0 Journal Article
%T Investigation of a spherical-section ultrasound phased array for hepatic ablation
%A ZHANG Chen-xi
%A CHEN Ya-zhu
%J Journal of Zhejiang University SCIENCE A
%V 8
%N 8
%P 1237-1245
%@ 1673-565X
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.A1237

TY - JOUR
T1 - Investigation of a spherical-section ultrasound phased array for hepatic ablation
A1 - ZHANG Chen-xi
A1 - CHEN Ya-zhu
J0 - Journal of Zhejiang University Science A
VL - 8
IS - 8
SP - 1237
EP - 1245
%@ 1673-565X
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.A1237


Abstract: 
A 3D ultrasound thermal model with a 3D finite element representation for modeling the thermal diffusion effects for hepatic ablation induced by spherical-section ultrasound phased array was developed. The model was first validated against available published measured data in rat liver. Using the validated model, effects of blood perfusion and heating schemes on lesion formation were studied for both single focus and split-focus intensity patterns. It was shown that for single focus sonication pattern the short-duration (~2 s) and high-intensity (~1250 W/cm2) heating scheme can completely reduce the cooling effect of the blood perfusion. The lesion shape and size were significantly altered by perfusion for split-focus pattern even with a rapid heating scheme when the focus spacing was larger than 2.4 mm. Underdosed areas might be present between two foci. Prolonging exposure time or shortening focus spacing can reduce the cool region between two foci. In addition, the influences of thermal and acoustic parameters were also studied. When the therapy depth is short (<5 cm), the lesion size monotonically increases with increasing attenuation coefficient that ranges from 5.4 to 11 Np/(m∙MHz).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Chen, L.L., ter Haar, G.R., Hill, C.R., Dworkin, M., Carnochan, P., Young, H., Bensted, J.P.M., 1993. Effect of blood perfusion on the ablation of liver parenchyma with high-intensity focused ultrasound. Phys. Med. Biol., 38(11):1661-1673.

[2] Cheng, K.S., Roemer, R.B., 2005. Blood perfusion and thermal conduction effects in Gaussian beam, minimum time single-pulse thermal therapies. Med. Phys., 32(2):311-317.

[3] Curra, F.P., Mourad, P.D., Khokhlova, V.A., Cleveland, R.O., Crum, L.A., 2000. Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound. IEEE Trans. on Ultrason. Ferroelectr. Freq. Control, 47(4):1077-1088.

[4] Ebbini, E.S., Cain, C.A., 1989. Multiple-focused ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia. IEEE Trans. on Ultrason. Ferroelectr. Freq. Control, 36(5):540-548.

[5] Fan, X., Hynynen, K., 1992. The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments. J. Acoust. Soc. Am., 91(3):1727-1736.

[6] Fan, X., Hynynen, K., 1994. The effects of curved tissue layers on the power deposition patterns of therapeutic ultrasound beams. Med. Phys., 21(1):25-34.

[7] Gertner, M.R., Wilson, B.C., Sherar, M.D., 1997. Ultrasound properties of liver tissue during heating. Ultrasound in Med. & Biol., 23(9):1395-1403.

[8] Graham, S.J., Chen, L., Leitch, M., Peters, R.D., Bronskill, M.J., Foster, F.S., Henkelman, R.M., Plewes, D.B., 1999. Quantifying tissue damage due to focused ultrasound heating observed by MRI. Magn. Reson. Med., 41(2):321-328.

[9] Huang, J.L., Holt, R.G., Cleveland, R.O., Roy, R.A., 2004. Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms. J. Acoust. Soc. Am., 116(4):2451-2458.

[10] Kolios, M.C., Sherar, M.D., Hunt, J.W., 1996. Blood flow cooling and ultrasonic lesion formation. Med. Phys., 23(7):1287-1298.

[11] Kudo, M., Murakami, T., Hashimoto, K., Hori, M., Kim, T., Nakamura, H., 2004. Comparison of the Hepatic Perfusion Parameters in Patients with Normal and Chronic Liver Disease. 90th Scientific Assembly and Annual Meeting of the RSNA. Chicago.

[12] Li, G.W., 2001. Research of High Intensity Focused Ultrasound Phased Array and Treatment Thermal Field. Ph.D Thesis, Shanghai Jiao Tong University, China (in Chinese).

[13] Li, F., Feng, R., Zhang, Q., Bai, J., Wang, Z., 2006. Estimation of HIFU induced lesions in vitro: numerical simulation and experiment. Ultrasonics, 44(S1):337-340.

[14] Liu, D.L., Saito, M., 1989. A new method for estimating the acoustic attenuation coefficient of tissue from reflected ultrasonic signals. IEEE Trans. on Med. Imaging, 8(1):107-110.

[15] Lu, M., Wan, M., Xu, F., Wang, X., Chang, X., 2006. Design and experiment of 256-element ultrasound phased array for noninvasive focused ultrasound surgery. Ultrasonics, 44(S1):325-330.

[16] Mahoney, K., Fjield, T., McDannold, N., Clement, G., Hynynen, K., 2001. Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning. Phys. Med. Biol., 46(7):1785-1798.

[17] Meaney, P.M., Clarke, R.L., ter Haar, G.R., Rivens, I.H., 1998. A 3-D finite-element model for computation of temperature profiles and regions of thermal damage during focused ultrasound surgery exposures. Ultrasound in Med. & Biol., 24(9):1489-1499.

[18] Meaney, P.M., Cahill, M.D., ter Haar, G.R., 2000. The intensity-dependence of lesion position shift during focused ultrasound surgery. Ultrasound in Med. & Biol., 26(3):441-450.

[19] Panescu, D., Whayne, J.G., Fleischman, S.D., Mirotznik, M.S., Swanson, D.K., Webster, J.G., 1995. Three-dimensional finite element analysis of current density and temperature distribution during radio-frequency ablation. IEEE Trans. on Biomed. Eng., 42(9):879-890.

[20] Pennes, H.H., 1948. Analysis of tissue and arterial blood temperatures in the resting human forearm. J. Appl. Phys., 1(2):93-122.

[21] Persson, J., Hansen, E., Lidgern, L., McCarthy, I., 2005. Modeling of the heat distribution in the intervertebral disk. Ultrasound in Med. & Biol., 31(5):709-717.

[22] Sapareto, S.A., Dewey, W., 1984. Thermal dose determination in cancer. Int. J. Radiat. Oncol. Biol. Phys., 10(6):787-800.

[23] Sasaki, K., Azuma, T., Kawabata, K.I., Shimoda, M., Kokue, E.I., Umemura, S.I., 2003. Effect of split-focus approach on producing larger coagulation in swine liver. Ultrasound in Med. & Biol., 29(4):591-609.

[24] Valvano, J.W., Cochran, J.R., Diller, K.R., 1985. Thermal conductivity and diffusivity of biomaterials measured with self-heating thermistors. Int. J. Thermophys., 6(3):301-311.

[25] Zderic, V., Keshavarzi, A., Andrew, M.A., Vaezy, S., Martin, R.W., 2004. Attenuation of porcine tissues in vivo after high intensity ultrasound treatment. Ultrasound in Med. & Biol., 30(1):61-66.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE