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Received: 2006-12-06
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SHI Zheng-zheng, ZHANG Jia-wei, ZHENG Shu. What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?[J]. Journal of Zhejiang University Science B, 2007, 8(3): 170-176.
@article{title="What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?",
author="SHI Zheng-zheng, ZHANG Jia-wei, ZHENG Shu",
journal="Journal of Zhejiang University Science B",
volume="8",
number="3",
pages="170-176",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0170"
}
%0 Journal Article
%T What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?
%A SHI Zheng-zheng
%A ZHANG Jia-wei
%A ZHENG Shu
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 3
%P 170-176
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0170
TY - JOUR
T1 - What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?
A1 - SHI Zheng-zheng
A1 - ZHANG Jia-wei
A1 - ZHENG Shu
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 3
SP - 170
EP - 176
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0170
Abstract: This article is to summarize the molecular and functional analysis of the gene “suppression of tumorigenicity 13” (ST13). ST13 is in fact the gene encoding Hsp70 interacting protein (hip), a co-factor (co-chaperone) of the 70-kDa heat shock proteins (hsc/Hsp70). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), hip facilitates may facilitate the chaperone function of hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis. Although the nomenclature of ST13 implies a role in the suppression of tumorigenicity (ST), to date available experimental data are not sufficient to support its role in cancer development, except for the possible down-regulation of ST13 in gastric and colorectal cancers. Further investigation of this gene at the physiological level would benefit our understanding of diseases such as endocrinological disorders, cancer, and neurodegeneration commonly associated with protein misfolding.
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