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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.6 P.428-434

http://doi.org/10.1631/jzus.2007.B0428


Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index


Author(s):  XIANG Yan, LI Yu-hong

Affiliation(s):  Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   yuh_li2002@hotmail.com

Key Words:  Propofol, Lidocaine, Ropivacaine, Epidural anethesia, Bispectral index


XIANG Yan, LI Yu-hong. Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index[J]. Journal of Zhejiang University Science B, 2007, 8(6): 428-434.

@article{title="Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index",
author="XIANG Yan, LI Yu-hong",
journal="Journal of Zhejiang University Science B",
volume="8",
number="6",
pages="428-434",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0428"
}

%0 Journal Article
%T Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index
%A XIANG Yan
%A LI Yu-hong
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 6
%P 428-434
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0428

TY - JOUR
T1 - Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index
A1 - XIANG Yan
A1 - LI Yu-hong
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 6
SP - 428
EP - 434
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0428


Abstract: 
Objective: To compare the effects of epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine on propofol requirements, the time to loss of consciousness (LOC), effect-site propofol concentrations, and the hemodynamic variables during induction of general anesthesia guided by bispectral index (BIS) were studied. Methods: Forty-five patients were divided into three groups to receive epidurally administered saline (Group S), 1.5% (w/w) lidocaine (Group L), or 0.5% (w/w) ropivacaine (Group R). propofol infusion was started to produce blood concentration of 4 μg/ml. Once the BIS value reached 40~50, endotracheal intubation was facilitated by 0.1 mg/kg vecuronium. Measurements included the time to LOC, effect-site propofol concentrations, total propofol dose, mean arterial blood pressure (MABP), and heart rate (HR) at different study time points. Results: During induction of anesthesia, both Groups L and R were similar for the time to LOC, effect-site propofol concentrations, total propofol dose, MABP, HR, and BIS. The total doses of propofol administered until 1 min post-intubation were significantly less in patients of Groups R and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or MABP was significantly increased following intubation as compared with that prior to intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups. Conclusion: Epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine has similar effects on the time to LOC, effect-site propofol concentrations, total propofol dose, and the hemodynamic variables during induction of general anesthesia.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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