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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.8 P.570-574


Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study

Author(s):  LU Xing-guo, WU Xian-guo, XU Xiao-hua, GONG Xu-bo, ZHOU Xuan, XU Gen-bo, ZHU Lei, ZHAO Xiao-ying

Affiliation(s):  Department of Haematology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   xgwu1973@163.com

Key Words:  Tissue extract, Fibrinolytic factors, Fibrinolytic inhibitors

LU Xing-guo, WU Xian-guo, XU Xiao-hua, GONG Xu-bo, ZHOU Xuan, XU Gen-bo, ZHU Lei, ZHAO Xiao-ying. Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study[J]. Journal of Zhejiang University Science B, 2007, 8(8): 570-574.

@article{title="Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study",
author="LU Xing-guo, WU Xian-guo, XU Xiao-hua, GONG Xu-bo, ZHOU Xuan, XU Gen-bo, ZHU Lei, ZHAO Xiao-ying",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study
%A LU Xing-guo
%A WU Xian-guo
%A XU Xiao-hua
%A GONG Xu-bo
%A ZHOU Xuan
%A XU Gen-bo
%A ZHU Lei
%A ZHAO Xiao-ying
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 8
%P 570-574
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0570

T1 - Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study
A1 - LU Xing-guo
A1 - WU Xian-guo
A1 - XU Xiao-hua
A1 - GONG Xu-bo
A1 - ZHOU Xuan
A1 - XU Gen-bo
A1 - ZHU Lei
A1 - ZHAO Xiao-ying
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 8
SP - 570
EP - 574
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0570

Objective: The purpose of this work was to investigate the distribution pattern of fibrinolytic factors and their inhibitors in rabbit tissues. Methods: The components of the fibrinolytic system in extracts from a variety of rabbit tissues, including tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), plasminogen (Plg), plasmin (Pl) and α2 plasmin inhibitor (α2PI), were determined by colorimetric assay. Results: The tissue extracts in renal, small intestine, lung, brain and spleen demonstrated strong fibrinolytic function, in which high activity of tPA, Plg and Pl was manifested; whereas in skeletal muscle, tongue and stomach, higher activity of PAI-1 and α2PI showed obviously. Also excellent linear correlations were found between levels of tPA and PAI-1, Pl and α2PI, Plg and Pl. In related tissues, renal cortex and renal marrow showed distinctly higher activity of tPA and lower activity of PAI-1, with the levels of Plg and Pl in renal cortex being higher than those in renal marrow, where the α2PI level was higher than that in renal cortex. Similarly, the levels of tPA, Plg and Pl in small intestine were higher than those in large intestine, but with respect to PAI-1 and α2PI, the matter was reverse. In addition, the fibrinolytic activity in muscle tissue was lower, however, the levels of tPA, Plg, and Pl in cardiac muscle were obviously higher than those in skeletal muscles, and the levels of PAI-1 and α2PI were significantly lower than those in skeletal muscle. Conclusion: Our data demonstrate that a remarkable difference of the fibrinolytic patterns exists in rabbit tissues, which has probable profound significance in understanding the relationship between the function of haemostasis or thrombosis and the physiologic function in tissues.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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