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Received: 2007-08-27

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.2 P.141-147


Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties

Author(s):  Mariappan BALAMURUGAN, Kasi PARTHASARATHI, Lalpet Souri RANGANATHAN, Edwin L. COOPER

Affiliation(s):  Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalai Nagar-608002, India; more

Corresponding email(s):   dnabala@rediffmail.com

Key Words:  Earthworm extract, Hepatoprotective potential, Antioxidant, Paracetamol, Lipid peroxidation

Mariappan BALAMURUGAN, Kasi PARTHASARATHI, Lalpet Souri RANGANATHAN, Edwin L. COOPER. Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties[J]. Journal of Zhejiang University Science B, 2008, 9(2): 141-147.

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publisher="Zhejiang University Press & Springer",

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%DOI 10.1631/jzus.B0720194

T1 - Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties
A1 - Mariappan BALAMURUGAN
A1 - Lalpet Souri RANGANATHAN
A1 - Edwin L. COOPER
J0 - Journal of Zhejiang University Science B
VL - 9
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0720194

The hepatoprotective potential of earthworm extract (EE) (Lampito mauritii, Kinberg) was evaluated against paracetamol-induced liver injury in Wistar albino rat, in comparison with silymarin, the standard hepatoprotective drug. We observed a reduction in liver antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) and in serum total protein, and an increase in serum alkaline phosphatase (ALP), serum aspertate aminotranferase (AST), serum alanine aminotranferase (ALT), bilirubin and liver thiobarbituric acid reactive substances (TBARS) due to liver injury in the paracetamol-administered rats (2 g/kg). On the contrary, increased activities of liver GSH, SOD, GPx, CAT and serum total protein level, and decrease in the contents of serum ALP, AST, ALT, bilirubin and liver TBARS were observed in rats administered with different doses of EE (100, 200 and 300 mg/kg), which are similar to the activities of hepatoprotective drug silymarin (150 mg/kg). The mode of action of EE as evidenced by the above parameters may suggest that EE, on the one hand, prevents the formation of the reactive oxygen groups, or scavenges these groups, thereby preventing the damage on the hepatic cells, and, on the other hand, modulates the genes responsible for synthesis of antioxidant enzymes such as GPx, CAT and SOD in liver tissue and decreases the serum enzymatic activities such as ALP, AST and ALT.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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Open peer comments: Debate/Discuss/Question/Opinion


Dr.Balamurugan@Annamalai university<dnabala@rediffmail.com>

2011-02-05 13:32:03

Dear Respected Prof

Thank you for your kind correction.....

Dr. Nahida@Kashmir University<n.tabassum.uk@gmail .com>

2010-10-15 15:11:01

To Whom it may concern,

Kindly note the name of the Journal in Reference No: 32,

Tabassum, N., Chattervedi, S., Aggrawal, S., Ahmed, N., 2005. Hepatoprotective studies on Phyllanthus niruri paracetamol induced liver cell damage in albino mice. Experimental Medicine, 12(4):211-212.

is JK Practitioner and not Experimental Medicine which is a section of the Journal in wich Experimental Work is published.

I hope this mistake will be rectified.

With Regards,
Dr. Nahida tabassum, Deptt. of Pharmaceutical Sciences,
Kashmir University,
J&k, India-190006

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