Full Text:   <2919>

Summary:  <1611>

CLC number: R698

On-line Access: 2015-03-05

Received: 2014-07-13

Revision Accepted: 2014-10-31

Crosschecked: 2015-02-21

Cited: 10

Clicked: 5170

Citations:  Bibtex RefMan EndNote GB/T7714


Thawatchai Prabsattroo


Jintanaporn Wattanathorn


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.3 P.179-190


Moringa oleifera extract enhances sexual performance in stressed rats

Author(s):  Thawatchai Prabsattroo, Jintanaporn Wattanathorn, Sitthichai Iamsaard, Pichet Somsapt, Opass Sritragool, Wipawee Thukhummee, Supaporn Muchimapura

Affiliation(s):  Graduate School and Department of Physiology (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; more

Corresponding email(s):   backwert@gmail.com, jintanapornw@yahoo.com

Key Words:  Moringa oleifera, Sexual behaviors, Stress

Thawatchai Prabsattroo, Jintanaporn Wattanathorn, Sitthichai Iamsaard, Pichet Somsapt, Opass Sritragool, Wipawee Thukhummee, Supaporn Muchimapura. Moringa oleifera extract enhances sexual performance in stressed rats[J]. Journal of Zhejiang University Science B, 2015, 16(3): 179-190.

@article{title="Moringa oleifera extract enhances sexual performance in stressed rats",
author="Thawatchai Prabsattroo, Jintanaporn Wattanathorn, Sitthichai Iamsaard, Pichet Somsapt, Opass Sritragool, Wipawee Thukhummee, Supaporn Muchimapura",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Moringa oleifera extract enhances sexual performance in stressed rats
%A Thawatchai Prabsattroo
%A Jintanaporn Wattanathorn
%A Sitthichai Iamsaard
%A Pichet Somsapt
%A Opass Sritragool
%A Wipawee Thukhummee
%A Supaporn Muchimapura
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 3
%P 179-190
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400197

T1 - Moringa oleifera extract enhances sexual performance in stressed rats
A1 - Thawatchai Prabsattroo
A1 - Jintanaporn Wattanathorn
A1 - Sitthichai Iamsaard
A1 - Pichet Somsapt
A1 - Opass Sritragool
A1 - Wipawee Thukhummee
A1 - Supaporn Muchimapura
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 3
SP - 179
EP - 190
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400197

Aphrodisiacs are required to improve male sexual function under stressful conditions. Due to the effects of oxidative stress and dopamine on male sexual function, we hypothesized that Moringa oleifera leaves might improve male sexual dysfunction induced by stress. Therefore, the effects on various factors playing important roles in male sexual behavior, such as antioxidant effects, the suppression of monoamine and phosphodiesterase type 5 (PDE-5) activities, serum testosterone and corticosterone levels, and histomorphological changes in the testes, of a hydroethanolic extract of M. oleifera leaves were investigated. Various doses of extract including 10, 50, and 250 mg/kg body weight (BW) were given orally to male Wistar rats before exposure to 12 h-immobilization stress for 7 d. The results demonstrated that the extract showed both antioxidant and monoamine oxidase type B (MAO-B) suppression activities. At 7 d of treatment, the low dose of extract improved sexual performance in stress-exposed rats by decreasing intromission latency and increasing intromission frequency. It also suppressed PDE-5 activity, decreased serum corticosterone level, but increased serum testosterone, numbers of interstitial cells of Leydig and spermatozoa. The increased numbers of interstitial cells of Leydig and spermatozoa might have been due to the antioxidant effect of the extract. The increased sexual performance during the intromission phase might have been due to the suppression of MAO-B and PDE-5 activities and increased testosterone. Therefore, M. oleifera is a potential aphrodisiac, but further research concerning the precise underlying mechanisms is still needed.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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