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Received: 2008-03-06

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.1 P.1-6


Estrogen receptor expression in adrenocortical carcinoma

Author(s):  Xiao-cao SHEN, Cai-xiao GU, Yi-qing QIU, Chuan-jun DU, Yan-biao FU, Jian-jun WU

Affiliation(s):  Urology Department; more

Corresponding email(s):   q_yiqing@yahoo.com

Key Words:  Adrenocortical carcinoma (ACC), Estrogen receptor (ER), Diagnosis, Treatment

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Xiao-cao SHEN, Cai-xiao GU, Yi-qing QIU, Chuan-jun DU, Yan-biao FU, Jian-jun WU. Estrogen receptor expression in adrenocortical carcinoma[J]. Journal of Zhejiang University Science B, 2009, 10(1): 1-6.

@article{title="Estrogen receptor expression in adrenocortical carcinoma",
author="Xiao-cao SHEN, Cai-xiao GU, Yi-qing QIU, Chuan-jun DU, Yan-biao FU, Jian-jun WU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Estrogen receptor expression in adrenocortical carcinoma
%A Xiao-cao SHEN
%A Cai-xiao GU
%A Yi-qing QIU
%A Chuan-jun DU
%A Yan-biao FU
%A Jian-jun WU
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 1
%P 1-6
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820072

T1 - Estrogen receptor expression in adrenocortical carcinoma
A1 - Xiao-cao SHEN
A1 - Cai-xiao GU
A1 - Yi-qing QIU
A1 - Chuan-jun DU
A1 - Yan-biao FU
A1 - Jian-jun WU
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 1
SP - 1
EP - 6
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820072

Objective: adrenocortical carcinoma (ACC) is a rare but highly malignant tumor, and its diagnosis is mostly delayed and prognosis is poor. We report estrogen receptor (ER) expression in this tumor and our clinical experiences with 17 ACC cases. Methods: The data of the 17 patients (9 females and 8 males, age range from 16 to 69 years, mean age of 42.6 years) with ACC were reviewed, and symptoms, diagnostic procedures, treatment, and results of follow-up were evaluated. Immunohistochemistry was used to detect ER expression in tumor samples from the 17 patients. Results: At the time of diagnosis, 4 tumors were classified as Stage I, 4 as Stage II, 3 as Stage III, and 6 as Stage IV. Eight patients demonstrated positive nuclear immunostaining of ER. The prognosis of patients with ER positive was significantly better (P<0.05) than that of patients with ER negative, with 1- and 5-year survival rates at 86% and 60% for ER-positive patients, and 38% and 0% for ER-negative patients, respectively. Conclusion: ER-positivity may be one of the factors associated with a worse prognosis of ACC.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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