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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.2 P.147-153


Anti-allergic effects of ethanol extracts from brown seaweeds

Author(s):  Haider SAMEE, Zhen-xing LI, Hong LIN, Jamil KHALID, Yong-chao GUO

Affiliation(s):  Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; more

Corresponding email(s):   linhong@ouc.edu.cn

Key Words:  Anti-allergic activity, Brown seaweed, Ethanol extracts, Hyaluronidase, Phlorotannin

Haider SAMEE, Zhen-xing LI, Hong LIN, Jamil KHALID, Yong-chao GUO. Anti-allergic effects of ethanol extracts from brown seaweeds[J]. Journal of Zhejiang University Science B, 2009, 10(2): 147-153.

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author="Haider SAMEE, Zhen-xing LI, Hong LIN, Jamil KHALID, Yong-chao GUO",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Anti-allergic effects of ethanol extracts from brown seaweeds
%A Haider SAMEE
%A Zhen-xing LI
%A Hong LIN
%A Yong-chao GUO
%J Journal of Zhejiang University SCIENCE B
%V 10
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%P 147-153
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820185

T1 - Anti-allergic effects of ethanol extracts from brown seaweeds
A1 - Haider SAMEE
A1 - Zhen-xing LI
A1 - Hong LIN
A1 - Jamil KHALID
A1 - Yong-chao GUO
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 2
SP - 147
EP - 153
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820185

ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities. They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan, and Sargassum graminifolium turn (SG), Sargassum thunbergii (STH), and Laminaria japonica (LJ) from China. The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of phlorotannin, an inhibitor against hyaluronidase. Total phlorotannins contained in the crude extracts were measured as 1.71% (SG), 0.74% (STH), 0.97% (LJ), 3.30% (SC), and 5.06% (ST). The 50% inhibitory concentrations (IC50) of Pakistani SC and ST were 109.5 and 21 μg/ml, respectively, lower than those of Chinese SG, STH, and LJ (134, 269, and 148 μg/ml, respectively). An antiallergic drug, disodium cromoglycate (DSCG), had an IC50=39 μg/ml, and a natural inhibitor of hyaluronidase, catechin, had an IC50=20 μg/ml. The IC50 of ST extract was found similar to that of catechin (21 vs 20 μg/ml) and lower than that of DSCG (21 vs 39 μg/ml). This suggests that ST is a potent inhibitor of hyaluronidase, indicating a promising future development of natural antiallergic medicines or functional foods.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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