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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.3 P.203-210

http://doi.org/10.1631/jzus.B0820213


Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats


Author(s):  He LI, Xiao-qing MA, Fan YE, Jing ZHANG, Xin ZHOU, Zhi-hong WANG, Yu-ming LI, Guo-yuan ZHANG

Affiliation(s):  Cardiovascular Division, Department of Geriatric Medicine, Pingjin Hospital, Medical College of Chinese People’ more

Corresponding email(s):   hli_tianjin@yahoo.com.cn

Key Words:  Norepinephrine transporter (NET), &beta, 1-adrenergic receptor (&beta, 1-AR), Cardiac sympathetic ganglion, Aging


He LI, Xiao-qing MA, Fan YE, Jing ZHANG, Xin ZHOU, Zhi-hong WANG, Yu-ming LI, Guo-yuan ZHANG. Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats[J]. Journal of Zhejiang University Science B, 2009, 10(3): 203-210.

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author="He LI, Xiao-qing MA, Fan YE, Jing ZHANG, Xin ZHOU, Zhi-hong WANG, Yu-ming LI, Guo-yuan ZHANG",
journal="Journal of Zhejiang University Science B",
volume="10",
number="3",
pages="203-210",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820213"
}

%0 Journal Article
%T Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats
%A He LI
%A Xiao-qing MA
%A Fan YE
%A Jing ZHANG
%A Xin ZHOU
%A Zhi-hong WANG
%A Yu-ming LI
%A Guo-yuan ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 3
%P 203-210
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820213

TY - JOUR
T1 - Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats
A1 - He LI
A1 - Xiao-qing MA
A1 - Fan YE
A1 - Jing ZHANG
A1 - Xin ZHOU
A1 - Zhi-hong WANG
A1 - Yu-ming LI
A1 - Guo-yuan ZHANG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 3
SP - 203
EP - 210
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820213


Abstract: 
Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the &beta;-adrenergic receptor (&beta;-AR). In the present study, we investigated NET and &beta;1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and &beta;1-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.

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