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CLC number: R742

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Received: 2008-11-22

Revision Accepted: 2009-03-25

Crosschecked: 2009-04-28

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.7 P.505-511


Effects of carnosine on the evoked potentials in hippocampal CA1 region

Author(s):  Zhou-yan FENG, Xiao-jing ZHENG, Jing WANG

Affiliation(s):  Key Lab of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   hnfzy@yahoo.com.cn

Key Words:  Carnosine, Hippocampus, Evoked potential, Epileptic seizure

Zhou-yan FENG, Xiao-jing ZHENG, Jing WANG. Effects of carnosine on the evoked potentials in hippocampal CA1 region[J]. Journal of Zhejiang University Science B, 2009, 10(7): 505-511.

@article{title="Effects of carnosine on the evoked potentials in hippocampal CA1 region",
author="Zhou-yan FENG, Xiao-jing ZHENG, Jing WANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of carnosine on the evoked potentials in hippocampal CA1 region
%A Zhou-yan FENG
%A Xiao-jing ZHENG
%A Jing WANG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 7
%P 505-511
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820370

T1 - Effects of carnosine on the evoked potentials in hippocampal CA1 region
A1 - Zhou-yan FENG
A1 - Xiao-jing ZHENG
A1 - Jing WANG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 7
SP - 505
EP - 511
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820370

Objective: To directly examine the effects of carnosine on neuronal excitation and inhibition in rat hippocampus in vivo. Methods: Artificial cerebrospinal fluid with carnosine was directly administrated over the exposed rat hippocampus. The changes of neuron activity in the CA1 region of hippocampus were evaluated by orthodromically- and antidromically-evoked potentials, as well as paired-pulse stimulation paradigm. Results: In both orthodromic and antidromic response potentials, carnosine transformed population spikes (PSs) with single spike into epileptiform multiple spikes. In addition, similar to the effect of (-aminobutyric acidA (GABAA) antagonist picrotoxin, carnosine decreased paired-pulse stimulating depression significantly. However, no significant change was observed in the spontaneous field potentials during the application of carnosine. Conclusion: The results indicate a disinhibition-induced excitation effect of carnosine on the CA1 pyramidal neurons. It provides important information against the application of carnosine as a potential anticonvulsant in clinical treatment.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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