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Received: 2001-07-02

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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.5 P.591-593


The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus

Author(s):  FENG Zhou-yan, ZHENG Xiao-xiang

Affiliation(s):  College of Life Sciences, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   zxx@mail.hz.zj.cn

Key Words:  Field potential, Dentate gyrus, Jujuboside A(JuA), Inhibitory effect

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FENG Zhou-yan, ZHENG Xiao-xiang. The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus[J]. Journal of Zhejiang University Science A, 2002, 3(5): 591-593.

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T1 - The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus
A1 - FENG Zhou-yan
A1 - ZHENG Xiao-xiang
J0 - Journal of Zhejiang University Science A
VL - 3
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SP - 591
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2002.0591

Jujuboside A (JuA) is a main component of Jujubogenin extracted from the seeds of Ziziphus. The authors have not seen any report on JuA's direct effect on the neurons of the central nervous system. This study aimed to assess the effect of JuA on paired-pulse responses of dentate gyrus granule cells in urethane-anaesthetized rats, used intracerebroventricular (i.c.v.) JuA to mimic in vitro bath conditions in vivo. Paired-pulse stimuli with 80 ms interpulse interval were used to stimulate the perforant pathway. Evoked responses were recorded in the dentate gyrus cell layer after i.c.v. administration of 0.9% normal saline or JuA. In the first responses, the slopes of excitatory postsynaptic potential (EPSP1) and the amplitudes of population spike (PS1) decreased significantly after administration of JuA while the PS1 latencies increased significantly. In the second responses, the EPSP2 slopes and PS2 latencies were changed similarly to those of the first ones, but PS2 amplitudes increased. The results showed that JuA may have some inhibitory effect on the granule cell excitability mediated by presynaptic mechanism but may have little effect on the excitability mediated by postsynaptic mechanism since the second evoked N-methyl-D-aspartic mediating paired-pulse facilitation is a postsynaptic mechanism.

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