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Received: 2008-12-26

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.7 P.499-504

http://doi.org/10.1631/jzus.B0820409


Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT


Author(s):  Sheng-yong WU, Hui-hui JIA, Didier HANS, Jing LAN, Li-ying WANG, Jing-xue LI, Yue-zeng CAI

Affiliation(s):  Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China; more

Corresponding email(s):   caiyuezeng@163.com

Key Words:  Osteoporosis, Bone mineral density (BMD), Volumetric QCT, Hip fracture, Postmenopausal women


Sheng-yong WU, Hui-hui JIA, Didier HANS, Jing LAN, Li-ying WANG, Jing-xue LI, Yue-zeng CAI. Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT[J]. Journal of Zhejiang University Science B, 2009, 10(7): 499-504.

@article{title="Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT",
author="Sheng-yong WU, Hui-hui JIA, Didier HANS, Jing LAN, Li-ying WANG, Jing-xue LI, Yue-zeng CAI",
journal="Journal of Zhejiang University Science B",
volume="10",
number="7",
pages="499-504",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820409"
}

%0 Journal Article
%T Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT
%A Sheng-yong WU
%A Hui-hui JIA
%A Didier HANS
%A Jing LAN
%A Li-ying WANG
%A Jing-xue LI
%A Yue-zeng CAI
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 7
%P 499-504
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820409

TY - JOUR
T1 - Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT
A1 - Sheng-yong WU
A1 - Hui-hui JIA
A1 - Didier HANS
A1 - Jing LAN
A1 - Li-ying WANG
A1 - Jing-xue LI
A1 - Yue-zeng CAI
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 7
SP - 499
EP - 504
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820409


Abstract: 
Objective: To demonstrate the validity and reliability of volumetric quantitative computed tomography (vQCT) with multi-slice computed tomography (MSCT) and dual energy X-ray absorptiometry (DXA) for hip bone mineral density (BMD) measurements, and to compare the differences between the two techniques in discriminating postmenopausal women with osteoporosis-related vertebral fractures from those without. Methods: Ninety subjects were enrolled and divided into three groups based on the BMD values of the lumbar spine and/or the femoral neck by DXA. Groups 1 and 2 consisted of postmenopausal women with BMD changes <−2SD, with and without radiographically confirmed vertebral fracture (n=11 and 33, respectively). Group 3 comprised normal controls with BMD changes ≥−1SD (n=46). Post-MSCT (GE, LightSpeed16) scan reconstructed images of the abdominal-pelvic region, 1.25 mm thick per slice, were processed by OsteoCAD software to calculate the following parameters: volumetric BMD values of trabecular bone (TRAB), cortical bone (CORT), and integral bone (INTGL) of the left femoral neck, femoral neck axis length (NAL), and minimum cross-section area (mCSA). DXA BMD measurements of the lumbar spine (AP-SPINE) and the left femoral neck (NECK) also were performed for each subject. Results: The values of all seven parameters were significantly lower in subjects of Groups 1 and 2 than in normal postmenopausal women (P<0.05, respectively). Comparing Groups 1 and 2, 3D-TRAB and 3D-INTGL were significantly lower in postmenopausal women with vertebral fracture(s) [(109.8±9.61) and (243.3±33.0) mg/cm3, respectively] than in those without [(148.9±7.47) and (285.4±17.8) mg/cm3, respectively] (P<0.05, respectively), but no significant differences were evident in AP-SPINE or NECK BMD. Conclusion: the femoral neck-derived volumetric BMD parameters using vQCT appeared better than the DXA-derived ones in discriminating osteoporotic postmenopausal women with vertebral fractures from those without. vQCT might be useful to evaluate the effect of osteoporotic vertebral fracture status on changes in bone mass in the femoral neck.

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