Full Text:   <2950>

CLC number: R58

On-line Access: 2010-03-10

Received: 2009-11-20

Revision Accepted: 2010-01-11

Crosschecked: 2010-02-03

Cited: 3

Clicked: 5542

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.3 P.218-220


Recurrent severe vomiting due to hyperthyroidism

Author(s):  Li-ying Chen, Bo Zhou, Zhou-wen Chen, Li-zheng Fang

Affiliation(s):  Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China, Department of Family Medicine, Community Health Services Center in Pengbu Town, Hangzhou 310017, China

Corresponding email(s):   hsh0906@163.com

Key Words:  Vomiting, Hyperthyroidism, Peptic ulcer

Li-ying Chen, Bo Zhou, Zhou-wen Chen, Li-zheng Fang. Recurrent severe vomiting due to hyperthyroidism[J]. Journal of Zhejiang University Science B, 2010, 11(3): 218-220.

@article{title="Recurrent severe vomiting due to hyperthyroidism",
author="Li-ying Chen, Bo Zhou, Zhou-wen Chen, Li-zheng Fang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Recurrent severe vomiting due to hyperthyroidism
%A Li-ying Chen
%A Bo Zhou
%A Zhou-wen Chen
%A Li-zheng Fang
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 3
%P 218-220
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900371

T1 - Recurrent severe vomiting due to hyperthyroidism
A1 - Li-ying Chen
A1 - Bo Zhou
A1 - Zhou-wen Chen
A1 - Li-zheng Fang
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 3
SP - 218
EP - 220
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900371

Thyrotoxicosis may present in many ways; severe vomiting as a prominent symptom of thyrotoxicosis is uncommon. In this paper, we report a 24-year-old Chinese male with hyperthyroidism who presented with recurrent severe vomiting. The patient had had intermittent vomiting for seven years and had lost approximately 15 kg of weight. Gastroscopic examinations revealed chronic gastritis and one occasion peptic ulcer. He was treated with antacid and proton pump inhibitors, but his symptoms had no relief. His presenting symptoms suggested hyperthyroidism and were confirmed by laboratory data. After a month of propylthiouracil therapy, his symptoms were relieved. It should be noted that hyperthyroidism patients can have unexplained vomiting, and that hyperthyroidism may coexist with peptic ulcer in rare cases. Awareness of such atypical presentations of hyperthyroidism may help to make a correct diagnosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Al Sayed, A., Al Awadhi, M., 2007. Old man presented with thyrotoxic vomiting. J. Med. Sci., 7(5):920-922.

[2]Aoyagi, K., Uehara, K., Ito, K., 1982. Gastric secretion in hyperthyroidism. Jpn J. Surg., 12(3):198-202.

[3]Bilezikian, J.P., Loeb, J.N., 1983. The influence of hyperthyroidism and hypothyroidism on alpha- and beta-adrenergic receptor systems and adrenergic responsiveness. Endocr. Rev., 4(4):378-388.

[4]Chen, P., Chen, H.F., Tan, S.W., Su, M.C., Ng, K.W., Jiang, C.F., 2003. Severely sustained vomiting as the main symptom in a man with thyrotoxicosis. J. Chin. Med. Assoc., 66(5):311-314.

[5]Crile, G., 1934. Hyperthyroidism and associated disease. Surg. Gynec. Obstet., 58:272-276.

[6]Garbat, A.L., 1951. The simultaneous occurrence of active peptic ulcer and active hyperthyroidism. J. Mount Sinai Hosp. NY, 17:787-792.

[7]Kisakol, G., Kayacetin, E., Sari, O., Kaya, A., 2003. Gastric emptying in subclinical hyperthyroidism. Neuro. Endocrinol. Lett., 24(3-4):255-258.

[8]Rosenthal, F.D., Jones, C., Lewis, S.I., 1976. Thyrotoxic vomiting. BMJ, 2(6029):209-211.

[9]Sellin, J.H., Vassiopoulou-Sellin, R., 2000. The Gastrointestinal Tract and Liver in Thyrotoxicosis. In: Braverman, L. (Ed.), Werner and Ingbar’s the Thyroid. Lippincott Williams and Wikin, Philadelphia, p.622-626.

[10]Xu, Z.S., Hu, X.J., Yang, G.J., Yan, C.G., Bao, Z.Y., 2007. Diagnosis analysis of 132 cases with vomiting as the main presentation due to hyperthyroidism. Chin. J. Pract. Intern. Med., 27(15):1215-1216.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE