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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.9 P.690-701

http://doi.org/10.1631/jzus.B1000008


Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?


Author(s):  Ning Zhou, Wei-xing Chen, Wei Zhang, Lan Li, Xi Jin, You-ming Li

Affiliation(s):  Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   zlym@zju.edu.cn

Key Words:  Helicobacter pylori, Eradication therapy, Short-term, Meta-analysis, Adverse effects


Ning Zhou, Wei-xing Chen, Wei Zhang, Lan Li, Xi Jin, You-ming Li. Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?[J]. Journal of Zhejiang University Science B, 2010, 11(9): 690-701.

@article{title="Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?",
author="Ning Zhou, Wei-xing Chen, Wei Zhang, Lan Li, Xi Jin, You-ming Li",
journal="Journal of Zhejiang University Science B",
volume="11",
number="9",
pages="690-701",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000008"
}

%0 Journal Article
%T Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?
%A Ning Zhou
%A Wei-xing Chen
%A Wei Zhang
%A Lan Li
%A Xi Jin
%A You-ming Li
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 9
%P 690-701
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000008

TY - JOUR
T1 - Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?
A1 - Ning Zhou
A1 - Wei-xing Chen
A1 - Wei Zhang
A1 - Lan Li
A1 - Xi Jin
A1 - You-ming Li
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 9
SP - 690
EP - 701
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000008


Abstract: 
Objective: The aim of our study was to perform a systematic review and meta-analysis of the efficacy of short-term protocols for Helicobacter pylori eradication and to review the safety and adverse profiles of these eradication protocols. Methods: Literatures were located through electronic searches by PubMed, Medline, ISI Web of Knowledge, and Cochrane Library using the relevant terms. Abstracts of important meetings were searched manually in some journal supplements. Additional bibliographies were identified from the reference lists of identified studies. Three independent reviewers systemically identified randomized controlled trials (RCTs) comparing short-duration protocols vs. 7-d proton pump inhibitor (PPI)-based triple protocols, as well as studies reporting eradication rates of short-duration protocols for H. pylori. Summary effect size was calculated as relative risk (RR) and 95% confidence intervals (CI) using Review Manager 4.2, and P<0.05 was defined as statistically significant in all analyses. Results: Among 90 abstracts retrieved, 15 studies were analyzed, including a total of 30 treatment regimens with 1856 subjects. Mean intention-to-treat (ITT) cure rates of 63.2% and 81.3% were achieved with short-term protocols and 7-d PPI-containing protocols, respectively. Per-protocol (PP)-based overall cure rates were 66.6% and 86.1%, respectively. short-term therapy was inferior to 7-d triple regimen (P<0.00001). After sub-analysis, however, comparing the effects of ≥3-d protocols and 7-d triple protocols, the cumulative ITT RR was 0.95 (P=0.26), and PP RR was 0.95 (P=0.10), without significant heterogeneity. Moreover, slightly fewer adverse-effects were found in short-term protocols. Conclusions: Although more economical, short-duration protocols are inferior to 7-d PPI-based triple protocols with regarding to eradication rate of H. pylori. Protocols of more than 3 d, however, may be equivalent to 7-d protocols.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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