CLC number: R573.9
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-09-11
Cited: 0
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Citations: Bibtex RefMan EndNote GB/T7714
Yan-yan Shi, Jing Zhang, Ting Zhang, Man Zhou, Ye Wang, He-jun Zhang, Shi-gang Ding. Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1[J]. Journal of Zhejiang University Science B, 2018, 19(10): 750-763.
@article{title="Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1",
author="Yan-yan Shi, Jing Zhang, Ting Zhang, Man Zhou, Ye Wang, He-jun Zhang, Shi-gang Ding",
journal="Journal of Zhejiang University Science B",
volume="19",
number="10",
pages="750-763",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700456"
}
%0 Journal Article
%T Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1
%A Yan-yan Shi
%A Jing Zhang
%A Ting Zhang
%A Man Zhou
%A Ye Wang
%A He-jun Zhang
%A Shi-gang Ding
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 10
%P 750-763
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700456
TY - JOUR
T1 - Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1
A1 - Yan-yan Shi
A1 - Jing Zhang
A1 - Ting Zhang
A1 - Man Zhou
A1 - Ye Wang
A1 - He-jun Zhang
A1 - Shi-gang Ding
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 10
SP - 750
EP - 763
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700456
Abstract: Helicobacter pylori infection is related to the development of gastric diseases. Our previous studies showed that high thioredoxin-1 (Trx1) expression in H. pylori can promote gastric carcinogenesis. To explore the underlying molecular mechanisms, we performed an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis of stomach tissues from Mongolian gerbil infected with H. pylori expressing high and low Trx1. Differences in the profiles of the expressed proteins were analyzed by bioinformatics and verified using Western blot analysis. We found three candidate proteins, 14-3-3α/β, glutathione-S-transferase (GST), and heat shock protein 70 (HSP70), in high Trx1 tissues compared with low Trx1 tissues and concluded that cellular stress and redox activity-related proteins were involved in the pathogenesis of gastric cancer associated with H. pylori Trx1.
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[49]List of electronic supplementary materials
[50]Table S1 Different expressed proteins for paired gastritis tissues infected by H. pylori expressing high or low Trx1
[51]Table S2 Different expressed proteins for paired dysplasia tissues infected by H. pylori expressing high or low Trx1
[52]Table S3 Different expressed proteins for paired gastric cancer tissues infected by H. pylori expressing high or low Trx1
[53]Table S4 Commonly and uniquely expressed 242 proteins in gastritis, dysplasia, and gastric cancer tissues infected by H. pylori expressing high or low Trx1
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