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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.5 P.365-371

http://doi.org/10.1631/jzus.B1000348


Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients


Author(s):  El?bieta Kimak, Magdalena Ha?abi?, Iwona Baranowicz-G?szczyk, Janusz Solski, Andrzej Ksi??ek

Affiliation(s):  Department of Laboratory Diagnostics, Medical University of Lublin, ul. Chod?ki 1, 20-093 Lublin, Poland, Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland

Corresponding email(s):   elzbieta.kimak@wp.pl, magdalenahalabis@gmail.com

Key Words:  Lipids, Lipoproteins, Paraoxonase-1 (PON-1) activity, Oxidized low-density lipoprotein (ox-LDL), High-density lipoprotein (HDL) particles, Post-renal transplant, Hemodialysis


El?bieta Kimak, Magdalena Ha?abi?, Iwona Baranowicz-G?szczyk, Janusz Solski, Andrzej Ksi??ek. Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients[J]. Journal of Zhejiang University Science B, 2011, 12(5): 365-371.

@article{title="Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients",
author="El?bieta Kimak, Magdalena Ha?abi?, Iwona Baranowicz-G?szczyk, Janusz Solski, Andrzej Ksi??ek",
journal="Journal of Zhejiang University Science B",
volume="12",
number="5",
pages="365-371",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000348"
}

%0 Journal Article
%T Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients
%A El?bieta Kimak
%A Magdalena Ha?abi?
%A Iwona Baranowicz-G?szczyk
%A Janusz Solski
%A Andrzej Ksi??ek
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 5
%P 365-371
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000348

TY - JOUR
T1 - Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients
A1 - El?bieta Kimak
A1 - Magdalena Ha?abi?
A1 - Iwona Baranowicz-G?szczyk
A1 - Janusz Solski
A1 - Andrzej Ksi??ek
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 5
SP - 365
EP - 371
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000348


Abstract: 
Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed (HD) and post-renal transplant (Tx) patients are proatherogenic, but elevated concentrations of plasma high-density lipoprotein (HDL) reduce the risk of cardiovascular disease. We investigated the concentrations of lipid, lipoprotein, HDL particle, oxidized low-density lipoprotein (ox-LDL) and anti-ox-LDL, and paraoxonase-1 (PON-1) activity in HD (n=33) and Tx (n=71) patients who were non-smokers without active inflammatory disease, liver disease, diabetes, or malignancy. HD patients had moderate hypertriglyceridemia, normocholesterolemia, low HDL-C, apolipoprotein A-I (apoA-I) and HDL particle concentrations as well as PON-1 activity, and increased ox-LDL and anti-ox-LDL levels. Tx patients had hypertriglyceridemia, hypercholesterolemia, moderately decreased HDL-C and HDL particle concentrations and PON-1 activity, and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference, but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients. However, in both patient groups, lipid and lipoprotein ratios (total cholesterol (TC)/HDL-C, LDL-C/HDL-C, triglyceride (TG)/HDL-C, HDL-C/non-HDL-C, apoA-I/apoB, HDL-C/apoA-I, TG/HDL) were atherogenic. The Spearman’s rank coefficient test showed that the concentration of ox-LDL correlated positively with HDL particle level (R=0.363, P=0.004), and negatively with TC (R=−0.306, P=0.012), LDL-C (R=−0.283, P=0.020), and non-HDL-C (R=−0.263, P=0.030) levels in Tx patients. Multiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration, as an independent variable, was associated significantly positively with HDL particle level. The results indicated that ox-LDL and decreased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs, which are less stable, easily undergo metabolic remodeling, generate a greater number of smaller pre-β-HDL particles, and thus accelerate reverse cholesterol transport, which may be beneficial for Tx patients. Further studies are necessary to confirm this.

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