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CLC number: X593

On-line Access: 2011-11-30

Received: 2010-12-19

Revision Accepted: 2011-08-29

Crosschecked: 2011-11-11

Cited: 6

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.12 P.969-975


Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe

Author(s):  Guo-qing Di, Bing Zhou, Zheng-guang Li, Qi-li Lin

Affiliation(s):  Institute for Environmental Pollution Control Technology, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   dgq@zju.edu.cn

Key Words:  Aircraft noise, Open field test, Norepinephrine, Neuron, Synapse

Guo-qing Di, Bing Zhou, Zheng-guang Li, Qi-li Lin. Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe[J]. Journal of Zhejiang University Science B, 2011, 12(12): 969-975.

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author="Guo-qing Di, Bing Zhou, Zheng-guang Li, Qi-li Lin",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe
%A Guo-qing Di
%A Bing Zhou
%A Zheng-guang Li
%A Qi-li Lin
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 12
%P 969-975
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000439

T1 - Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe
A1 - Guo-qing Di
A1 - Bing Zhou
A1 - Zheng-guang Li
A1 - Qi-li Lin
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 12
SP - 969
EP - 975
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000439

In order to investigate the physiological effects of airport noise exposure on organisms, in this study, we exposed Sprague-Dawley rats in soundproof chambers to previously recorded aircraft-related noise for 65 d. For comparison, we also used unexposed control rats. Noise was arranged according to aircraft flight schedules and was adjusted to its weighted equivalent continuous perceived noise levels (LWECPN) of 75 and 80 dB for the two experimental groups. We examined rat behaviors through an open field test and measured the concentrations of plasma norepinephrine (NE) by high performance liquid chromatography-fluorimetric detection (HPLC-FLD). We also examined the morphologies of neurons and synapses in the temporal lobe by transmission electron microscopy (TEM). Our results showed that rats exposed to airport noise of 80 dB had significantly lower line crossing number (P<0.05) and significantly longer center area duration (P<0.05) than control animals. After 29 d of airport noise exposure, the concentration of plasma NE of exposed rats was significantly higher than that of the control group (P<0.05). We also determined that the neuron and synapsis of the temporal lobe of rats showed signs of damage after aircraft noise of 80 dB exposure for 65 d. In conclusion, exposing rats to long-term aircraft noise affects their behaviors, plasma NE levels, and cell morphology of the temporal lobe.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Akdogan, O., Selcuk, A., Take, G., Erdoğan, D., Dere, H., 2009. Continuous or intermittent noise exposure, does it cause vestibular damage? An experimental study. Auris Nasus Larynx, 36(1):2-6.

[2]Baxter, M.G., 2009. Involvement of medial temporal lobe structures in memory and perception. Neuron, 61(5):667-677.

[3]Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., Lipton, S.A., 1995. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. PNAS, 92(16):7162-7166.

[4]Conrad, C.D., Magariños, A.M., LeDoux, J.E., McEwen, B.S., 1999. Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. Behav. Neurosci., 113(5):902-913.

[5]de Bartolomeis, A., Fiore, G., 2004. Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: implications for human behavior pathologies. Int. Rev. Neurobiol., 59:221-254.

[6]Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., Eisenhofer, G., 1990. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol. Rev., 70(4):963-985.

[7]Finlay, J.M., Zigmond, M.J., Abercrombie, E.D., 1995. Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: effects of diazepam. Neuroscience, 64(3):619-628.

[8]Franssen, E.A.M., van Wiechen, C.M.A.G., Nagelkerke, N.J.D., Lebret, E., 2004. Aircraft noise around a large international airport and its impact on general health and medication use. Occup. Environ. Med., 61(5):405-413.

[9]Goldstein, D.S., 1981. Plasma norepinephrine as an indicator of sympathetic neural activity in clinical cardiology. Am. J. Cardiol., 48(6):1147-1154.

[10]Hou, G.L., 2002. An experimental study on the damaging of non-steady state noise on free cardiac effect radical. Chin. J. Appl. Psychol., 8(4):47-50 (in Chinese).

[11]Hu, B.H., Henderson, D., Nicotera, T.M., 2002. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear. Res., 166(1-2):62-71.

[12]Hugdahl, K., Løberg, E.M., Nygård, M., 2009. Left temporal lobe structural and functional abnormality underlying auditory hallucinations in schizophrenia. Front. Neurosci., 3(1):34-45.

[13]Jarup, L., Babisch, W., Houthuijs, D., Pershagen, G., Katsouyanni, K., Cadum, E., Dudley, M.L., Savigny, P., Seiffert, I., Swart, W., et al., 2008. Hypertension and exposure to noise near airports: the HYENA study. Environ. Health Perspect., 6(3):329-333.

[14]Katz, R.J., Roth, K.A., Carroll, B.J., 1981. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci. Biobehav. Rev., 5(2):247-251.

[15]Knipschild, P., 1977. V. Medical effects of aircraft noise: community cardiovascular survey. Int. Arch. Occup. Environ. Health, 40(3):185-190.

[16]Krebs, H., Macht, M., Weyers, P., Weijers, H.G., Janke, W., 1996. Effects of stressful noise on eating and non-eating behavior in rats. Appetite, 26(2):193-202.

[17]Lake, C.R., Gullner, H.G., Polinsky, R.J., Ebert, M.H., Ziegler, M.G., Bartter, F.C., 1981. Essential hypertension: central and peripheral norepinephrine. Science, 211(4485):955-957.

[18]Li, H., Ma, X.Q., Ye, F., Zhang, J., Zhou, X., Wang, Z.H., Li, Y.M., Zhang, G.Y., 2009. Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats. J. Zhejiang Univ.-Sci. B, 10(3):203-210.

[19]Makino, S., Iwata, M., Fujiwara, M., Ike, S., Tateyama, H., 2006. A case of sleep apnea syndrome manifesting severe hypertension with high plasma norepinephrine levels. Endocr. J., 53(3):363-369.

[20]Matsui, T., Uehara, T., Miyakita, T., Hitamatsu, K., Osada, Y., Yamamoto, Y., 2004. The Okinawa study: effects of chronic aircraft noise on blood pressure and some other physiological indices. J. Sound Vib., 277(3):469-470.

[21]Murchison, C.F., Zhang, X.Y., Zhang, W.P., Ouyang, M., Lee, A., Thomas, S.A., 2004. A distinct role for norepinephrine in memory retrieval. Cell, 117(1):131-143.

[22]Okada, A., Ariizumi, M., Okamoto, G., 1983. Changes in cerebral norepinephrine induced by vibration or noise stress. Eur. J. Appl. Physiol., 52(1):94-97.

[23]Pan, F., Lu, C.Y., Song, J., Jing, H., Li, Q., Yu, H.L., Chen, X.Y., 2006. Short communication: different duration of crowding and noise exposure effects on exploratory behavior, cellular immunity and HSP70 expression in rats. Stress Health, 22(4):257-262.

[24]Raskind, M.A., Peskind, E.R., Halter, J.B., Jimerson, D.C., 1984. Norepinephrine and MHPG levels in CSF and plasma in Alzheimer’s disease. Arch. Gen. Psychiatry, 41(4):343-346.

[25]Samson, J., Sheeladevi, R., Ravindran, R., Senthilvelan, M., 2007. Stress response in rat brain after different durations of noise exposure. Neurosci. Res., 57(1):143-147.

[26]Silveira, P.P., Xavier, M.H., Souza, F.H., Manoli, L.P., Rosat, R.M., Ferreira, M.B., Dalmaz, C., 2000. Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats. Braz. J. Med. Biol. Res., 33(11):1343-1350.

[27]Spreng, M., 2000. Possible health effects of noise induced cortisol increase. Noise Health, 2(7):59-63.

[28]Suzuki, W.A., Baxter, M.G., 2009. Memory, perception, and the medial temporal lobe: a synthesis of opinions. Neuron, 61(5):678-679.

[29]Vaernes, R., Ursin, H., Darragh, A., Lambe, R., 1982. Endocrine response patterns and psychological correlates. J. Psychosom. Res., 26(2):123-131.

[30]Vicente-Torres, M.A., Gil-Loyzaga, P., 1999. Noise stimulation decreases the concentration of norepinephrine in the rat cochlea. Neurosci. Lett., 266(3):217-219.

[31]Vitale, G., Arletti, R., Sandrini, M., 2005. Acute noise stress analgesia in relation to 5-HT2 and μ-opioid receptor changes in the frontal cortex of young mice. Life Sci., 77(20):2500-2513.

[32]Walsh, R.N., Cummins, R.A., 1976. The open-field test: a critical review. Psychol. Bull., 83(3):482-504.

[33]Yasunari, K., Matsui, T., Maeda, K., Nakamura, M., Watanabe, T., Kiriike, N., 2006. Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension. Am. J. Hypertens., 19(6):573-578.

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