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CLC number: A1

On-line Access: 2016-09-07

Received: 2016-03-24

Revision Accepted: 2016-06-29

Crosschecked: 2016-08-08

Cited: 3

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Citations:  Bibtex RefMan EndNote GB/T7714


Homeira Zardooz


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.9 P.728-732


Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring

Author(s):  Roxana Karbaschi, Forouzan Sadeghimahalli, Homeira Zardooz

Affiliation(s):  Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; more

Corresponding email(s):   homeira_zardooz@sbmu.ac.ir

Key Words:  Maternal high-fat diet, Glucose tolerance test, Insulin, Homeostasis model assessment of insulin resistance (HOMA-IR), Corticosterone

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Roxana Karbaschi, Forouzan Sadeghimahalli, Homeira Zardooz. Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring[J]. Journal of Zhejiang University Science B, 2016, 17(9): 728-732.

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%T Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring
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DOI - 10.1631/jzus.B1600131

This study attempts to further clarify the potential effects of maternal high-fat (HF) diet on glucose homeostasis in dams and young adult male rat offspring. Female rats were divided into control (CON dams) and HF (HF dams) diet groups, which received the diet 4 weeks prior to and through pregnancy and lactation periods. Blood samples were taken to determine metabolic parameters, then an intraperitoneal glucose tolerance test (IPGTT) was performed. Maternal HF diet increased intra-abdominal fat mass and plasma corticosterone level, but decreased leptin concentration in dams. In HF offspring intra-abdominal fat mass, plasma leptin, and corticosterone levels decreased. Following IPGTT, the plasma insulin level of HF dams was higher than the controls. In HF offspring plasma insulin level was not significantly different from the controls, but a steeper decrease of their plasma glucose concentration was observed.




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