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CLC number: A1

On-line Access: 2016-09-07

Received: 2016-03-24

Revision Accepted: 2016-06-29

Crosschecked: 2016-08-08

Cited: 3

Clicked: 3160

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Homeira Zardooz

http://orcid.org/0000-0001-8307-1848

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.9 P.728-732

http://doi.org/10.1631/jzus.B1600131


Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring


Author(s):  Roxana Karbaschi, Forouzan Sadeghimahalli, Homeira Zardooz

Affiliation(s):  Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; more

Corresponding email(s):   homeira_zardooz@sbmu.ac.ir

Key Words:  Maternal high-fat diet, Glucose tolerance test, Insulin, Homeostasis model assessment of insulin resistance (HOMA-IR), Corticosterone


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Roxana Karbaschi, Forouzan Sadeghimahalli, Homeira Zardooz. Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring[J]. Journal of Zhejiang University Science B, 2016, 17(9): 728-732.

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publisher="Zhejiang University Press & Springer",
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Abstract: 
This study attempts to further clarify the potential effects of maternal high-fat (HF) diet on glucose homeostasis in dams and young adult male rat offspring. Female rats were divided into control (CON dams) and HF (HF dams) diet groups, which received the diet 4 weeks prior to and through pregnancy and lactation periods. Blood samples were taken to determine metabolic parameters, then an intraperitoneal glucose tolerance test (IPGTT) was performed. Maternal HF diet increased intra-abdominal fat mass and plasma corticosterone level, but decreased leptin concentration in dams. In HF offspring intra-abdominal fat mass, plasma leptin, and corticosterone levels decreased. Following IPGTT, the plasma insulin level of HF dams was higher than the controls. In HF offspring plasma insulin level was not significantly different from the controls, but a steeper decrease of their plasma glucose concentration was observed.

母代高脂饮食反向影响母鼠和子代成年雄性大鼠的胰岛素敏感度

目的:进一步明确母代高脂肪饮食对母鼠和子代成年雄鼠的葡萄糖稳态的潜在影响。
方法:将母代大鼠及其子代雄鼠(断奶后70天)分为对照组和高脂组,检测其血液代谢参数并进行腹腔内葡萄糖耐受试验。
结论:长期母代高脂肪饮食可能诱导母鼠的胰岛素抵抗,并改变子代的神经内分泌系统编程。

关键词:母代高脂饮食;葡萄糖耐量试验;胰岛素;稳态模型胰岛素抵抗指数;肾上腺酮

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Bellisario, V., Berry, A., Capoccia, S., et al., 2014. Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66Shc−/− mouse. Behav. Neurosci., 8:285.

[2]Cerf, M.E., Chapman, C.S., Louw, J., 2012. High-fat programming of hyperglycemia, hyperinsulinemia, insulin resistance, hyperleptinemia, and altered islet architecture in 3-month-old Wistar rats. ISRN Endocrinol., 2012:627270.

[3]Clegg, D.J., Gotoh, K., Kemp, C., et al., 2011. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol. Behav., 103(1):10-16.

[4]Desai, M., Jellyman, J.K., Han, G., et al., 2014. Rat maternal obesity and high fat diet program offspring metabolic syndrome. Am. J. Obstet., Gynecol., 211(3):237.e1-237.e13.

[5]Innis, S.M., 2005. Essential fatty acid transfer and fetal development. Placenta, 26(Suppl. A):S70-S75.

[6]Jacobs, S., Teixeira, D.S., Guilherme, C., et al., 2014. The impact of maternal consumption of cafeteria diet on reproductive function in the offspring. Physiol. Behav., 129(22):280-286.

[7]Kabaran, S., Besler, H.T., 2015. Do fatty acids affect fetal programming? J. Health Popul. Nutr., 33:14.

[8]Miotto, P.M., Castelli, L.M., Amoye, F., et al., 2013. Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male Wistar rat offspring at young adulthood. Molecules, 18(12):15094-15109.

[9]Mueller, W.M., Gregoire, F.M., Stanhope, K.L., et al., 1998. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology, 139(2):551-558.

[10]Rostamkhani, F., Zardooz, H., Zahediasl, S., et al., 2012. Comparison of the effects of acute and chronic psychological stress on metabolic features in rats. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(11):904-912.

[11]Srinivasan, M., Katewa, S.D., Palaniyappan, A., et al., 2006. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am. J. Physiol. Endocrinol. Metab., 291(4):E792-E799.

[12]Stuebe, A.M., Rich-Edwards, J.W., 2009. The reset hypothesis: lactation and maternal metabolism. Am. J. Perinatol., 26(1):81-88.

[13]Sullivan, E.L., Riper, K.M., Lockard, R., et al., 2015. Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm. Behav., 76:153-161.

[14]Tannenbaum, B.M., Brindley, D.N., Tannenbaum, G.S., 1997. High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat. Am. J. Physiol. Endocrinol. Metab., 273(6):E1168-E1177.

[15]Tuohetimulati, G., Uchida, T., Toyofuku, Y., et al., 2012. Effect of maternal high-fat diet on pancreatic beta cells of the offspring. Diabetol. Int., 3(4):217-223.

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