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CLC number: R587; R575.2

On-line Access: 2011-08-02

Received: 2010-12-30

Revision Accepted: 2011-06-24

Crosschecked: 2011-07-15

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.677-682

http://doi.org/10.1631/jzus.B1100001


Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis


Author(s):  Wei-feng Shan, Bing-quan Chen, Shao-jun Zhu, Li Jiang, Yan-feng Zhou

Affiliation(s):  Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   zyfhdj@yahoo.com

Key Words:  Glucose transporter-4 (GLUT4), Liver cirrhosis, Insulin resistance, Skeletal muscle


Wei-feng Shan, Bing-quan Chen, Shao-jun Zhu, Li Jiang, Yan-feng Zhou. Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis[J]. Journal of Zhejiang University Science B, 2011, 12(8): 677-682.

@article{title="Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis",
author="Wei-feng Shan, Bing-quan Chen, Shao-jun Zhu, Li Jiang, Yan-feng Zhou",
journal="Journal of Zhejiang University Science B",
volume="12",
number="8",
pages="677-682",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100001"
}

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%T Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis
%A Wei-feng Shan
%A Bing-quan Chen
%A Shao-jun Zhu
%A Li Jiang
%A Yan-feng Zhou
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 8
%P 677-682
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100001

TY - JOUR
T1 - Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis
A1 - Wei-feng Shan
A1 - Bing-quan Chen
A1 - Shao-jun Zhu
A1 - Li Jiang
A1 - Yan-feng Zhou
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 677
EP - 682
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100001


Abstract: 
Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin resistance. glucose transporter-4 (GLUT4), one of the most important glucose transporters, plays a key role in the development of type 2 diabetes. In order to study the mechanism of insulin resistance in liver cirrhosis patients, we measured the insulin sensitivity index and determined the GLUT4 protein and mRNA contents of skeletal muscle by Western blotting and reverse transcription-polymerase chain reaction (RT-PCR), respectively, in normal people and liver cirrhosis patients. The results showed that the levels of glucose, insulin, and C-peptide in two liver cirrhosis groups were higher and the insulin sensitivity index lower than those of the normal control group. The sensitivity of insulin may decrease with the decline of liver function. However, the contents of GLUT4 protein and mRNA in patients with advanced liver cirrhosis were similar to those of normal controls. In conclusion, insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA.

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Reference

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