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CLC number: R587.1

On-line Access: 2012-05-04

Received: 2011-08-04

Revision Accepted: 2012-01-18

Crosschecked: 2012-04-06

Cited: 9

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.5 P.372-377

http://doi.org/10.1631/jzus.B1100249


Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects


Author(s):  Hang Hu, Chun-mao Han, Xin-lei Hu, Wan-lan Ye, Wen-juan Huang, Andries J. Smit

Affiliation(s):  Department of Burns and Wound Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   hanchunmao1@126.com

Key Words:  Advanced glycation end-products (AGEs), Diabetic foot ulcerations, Screening


Hang Hu, Chun-mao Han, Xin-lei Hu, Wan-lan Ye, Wen-juan Huang, Andries J. Smit. Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects[J]. Journal of Zhejiang University Science B, 2012, 13(5): 372-377.

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author="Hang Hu, Chun-mao Han, Xin-lei Hu, Wan-lan Ye, Wen-juan Huang, Andries J. Smit",
journal="Journal of Zhejiang University Science B",
volume="13",
number="5",
pages="372-377",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100249"
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%T Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects
%A Hang Hu
%A Chun-mao Han
%A Xin-lei Hu
%A Wan-lan Ye
%A Wen-juan Huang
%A Andries J. Smit
%J Journal of Zhejiang University SCIENCE B
%V 13
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%P 372-377
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%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100249

TY - JOUR
T1 - Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects
A1 - Hang Hu
A1 - Chun-mao Han
A1 - Xin-lei Hu
A1 - Wan-lan Ye
A1 - Wen-juan Huang
A1 - Andries J. Smit
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 5
SP - 372
EP - 377
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100249


Abstract: 
Objective: This study was designed to evaluate the association between skin autofluorescence (AF), an indicator of advanced glycation end-products (AGEs), and foot ulcers in subjects with diabetes. Methods: In this study, 195 Chinese diabetic subjects were examined. Their feet were examined regardless of whether an ulcer was present or not. Skin AF was measured with an AGE reader. Demographic characteristics and blood data were recorded. Results: The mean values of skin AF were 2.29±0.47 for subjects without foot ulcers, and 2.80±0.69 for those with foot ulcers, a significant difference (P<0.05). Skin AF was strongly correlated with age and duration of diabetes. After adjusting for these factors, multivariate logistic regression showed that skin AF was independently associated with foot ulcerations. Conclusions: Skin AF is independently associated with diabetic foot ulcerations. It might be a useful screening method for foot ulceration risk of diabetic patients.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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