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CLC number: R587.2; R961

On-line Access: 2011-08-02

Received: 2011-06-29

Revision Accepted: 2011-07-05

Crosschecked: 2011-06-29

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.652-659

http://doi.org/10.1631/jzus.B1101004


Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats


Author(s):  Lin Lu, Wen-hui Peng, Wei Wang, Ling-jie Wang, Qiu-jing Chen, Wei-feng Shen

Affiliation(s):  Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China, Institute of Cardiovascular Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Corresponding email(s):   rjshenweifeng@yahoo.com.cn

Key Words:  Receptor for advanced glycation end-product (RAGE), Endogenous secretory RAGE (esRAGE), Soluble RAGE (sRAGE), Diabetic nephropathy, Atorvastatin


Lin Lu, Wen-hui Peng, Wei Wang, Ling-jie Wang, Qiu-jing Chen, Wei-feng Shen. Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats[J]. Journal of Zhejiang University Science B, 2011, 12(8): 652-659.

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author="Lin Lu, Wen-hui Peng, Wei Wang, Ling-jie Wang, Qiu-jing Chen, Wei-feng Shen",
journal="Journal of Zhejiang University Science B",
volume="12",
number="8",
pages="652-659",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1101004"
}

%0 Journal Article
%T Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats
%A Lin Lu
%A Wen-hui Peng
%A Wei Wang
%A Ling-jie Wang
%A Qiu-jing Chen
%A Wei-feng Shen
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 8
%P 652-659
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1101004

TY - JOUR
T1 - Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats
A1 - Lin Lu
A1 - Wen-hui Peng
A1 - Wei Wang
A1 - Ling-jie Wang
A1 - Qiu-jing Chen
A1 - Wei-feng Shen
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 652
EP - 659
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1101004


Abstract: 
Objective: Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE). This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat kidney. Methods: Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks). Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple methods. Renal AGEs, RAGE, endogenous secretory RAGE (esRAGE), and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. Results: Mesangial expansion and microalbuminuria were aggravated in diabetic rats, and improved with atorvastatin treatment. Serum sRAGE levels were lower in diabetic than in normal rats. After atorvastatin treatment, serum and renal sRAGE levels were up-regulated, while renal RAGE expression was decreased in diabetic rats, associated with a reduction in accumulation of AGEs, though renal esRAGE mRNA expression was not significantly increased. Conclusions: atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation, down-regulating RAGE expression and up-regulating sRAGE in the kidney.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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Open peer comments: Debate/Discuss/Question/Opinion

<1>

Nuray Ari@Prof<ari@ankara.edu.tr>

2011-08-11 10:19:22

very nice study...

Could you send me a full text of this article..

I am preparing a manuscript on pleiotropic effect of atorvastatin and want to add your article in the reference list.

thanks

sincerely yours...

Please provide your name, email address and a comment





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