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On-line Access: 2011-12-30

Received: 2011-08-24

Revision Accepted: 2011-11-30

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.1 P.35-42

http://doi.org/10.1631/jzus.B1100276


Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy


Author(s):  Barbara Ruszkowska, Alina Sokup, Arleta Kulwas, Maciej W. Socha, Krzysztof Gralczyk, Barbara Gralczyk, Danuta Ro??

Affiliation(s):  Department of Pathophysiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru?, Poland, Department of Gastroenterology, Angiology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru?, Poland, Department of Obstetrics, Gynecology and Oncological Gynecology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru?, Poland

Corresponding email(s):   ruszkowska.basia@gmail.com

Key Words:  Menopausal hormonal therapy (MHT), Plasminogen activator inhibitor type 1 (PAI-1), Leptin receptor, Ghrelin, Menopause


Barbara Ruszkowska, Alina Sokup, Arleta Kulwas, Maciej W. Socha, Krzysztof Gralczyk, Barbara Gralczyk, Danuta Ro??. Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy[J]. Journal of Zhejiang University Science B, 2012, 13(1): 35-42.

@article{title="Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy",
author="Barbara Ruszkowska, Alina Sokup, Arleta Kulwas, Maciej W. Socha, Krzysztof Gralczyk, Barbara Gralczyk, Danuta Ro??",
journal="Journal of Zhejiang University Science B",
volume="13",
number="1",
pages="35-42",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100276"
}

%0 Journal Article
%T Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy
%A Barbara Ruszkowska
%A Alina Sokup
%A Arleta Kulwas
%A Maciej W. Socha
%A Krzysztof Gralczyk
%A Barbara Gralczyk
%A Danuta Ro??
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 1
%P 35-42
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100276

TY - JOUR
T1 - Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy
A1 - Barbara Ruszkowska
A1 - Alina Sokup
A1 - Arleta Kulwas
A1 - Maciej W. Socha
A1 - Krzysztof Gralczyk
A1 - Barbara Gralczyk
A1 - Danuta Ro??
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 1
SP - 35
EP - 42
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100276


Abstract: 
Objective: In postmenopausal women, an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed. The aim of this study was to evaluate the concentrations of the active form of ghrelin, total ghrelin, leptin receptor, lipoprotein(a) (Lp(a)), and plasminogen activator inhibitor type 1 (PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy (MHT). Methods: The study involved 76 healthy women: 46 women aged from 44 to 58 years who received oral (26) or transdermal (20) MHT; the control group consisted of 30 women aged from 44 to 54 years who did not receive MHT. The plasma concentrations of total ghrelin, the active form of ghrelin, Lp(a), and PAI-1:Ag were measured by enzyme-linked immunosorbent assay (ELISA). The concentration of the leptin receptor was measured by enzyme immunometric assay (EIA). Results: We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral MHT. We also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group. A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control group. The differences were statistically significant. Additionally, we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal MHT. Conclusions: The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral MHT. This indicates a beneficial effect of the transdermal route of MHT. However, transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag, which in turn, can lead to a reduction in fibrinolytic activity.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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