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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.11 P.855-866


Nkx2-1: a novel tumor biomarker of lung cancer

Author(s):  Li Yang, Min Lin, Wen-jing Ruan, Liang-liang Dong, En-guo Chen, Xiao-hong Wu, Ke-jing Ying

Affiliation(s):  Department of Respiratory Medicine, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China; more

Corresponding email(s):   hzforest_yang@163.com, ykjsrrsh@163.com

Key Words:  Nkx2-1, TTF-1, Lung cancer, Biomarker, Diagnosis, Prognosis, Therapy

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Li Yang, Min Lin, Wen-jing Ruan, Liang-liang Dong, En-guo Chen, Xiao-hong Wu, Ke-jing Ying. Nkx2-1: a novel tumor biomarker of lung cancer[J]. Journal of Zhejiang University Science B, 2012, 13(11): 855-866.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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A1 - Li Yang
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A1 - Wen-jing Ruan
A1 - Liang-liang Dong
A1 - En-guo Chen
A1 - Xiao-hong Wu
A1 - Ke-jing Ying
J0 - Journal of Zhejiang University Science B
VL - 13
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1100382

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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