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CLC number: Q74; R34

On-line Access: 2013-03-06

Received: 2012-12-24

Revision Accepted: 2013-02-17

Crosschecked: 2013-02-18

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.3 P.171-177


Recent advances in the study of testicular nuclear receptor 4

Author(s):  Xian-fan Ding, Shi-cheng Yu, Bi-de Chen, Shin-jen Lin, Chawnshang Chang, Gong-hui Li

Affiliation(s):  Department of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   chang@urmc.rochester.edu, ligonghui1970@hotmail.com

Key Words:  NR2C2, TR4, Nuclear receptor, Gene knock out

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Xian-fan Ding, Shi-cheng Yu, Bi-de Chen, Shin-jen Lin, Chawnshang Chang, Gong-hui Li. Recent advances in the study of testicular nuclear receptor 4[J]. Journal of Zhejiang University Science B, 2013, 14(3): 171-177.

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author="Xian-fan Ding, Shi-cheng Yu, Bi-de Chen, Shin-jen Lin, Chawnshang Chang, Gong-hui Li",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200357

T1 - Recent advances in the study of testicular nuclear receptor 4
A1 - Xian-fan Ding
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A1 - Bi-de Chen
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A1 - Chawnshang Chang
A1 - Gong-hui Li
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1200357

Testicular nuclear receptor 4 (TR4), also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2), is a transcriptional factor and a member of the nuclear receptor family. TR4 was initially cloned from human and rat hypothalamus, prostate, and testes libraries. For almost two decades, its specific tissue distribution, genomic organization, and chromosomal assignment have been well investigated in humans and animals. However, it has been very difficult to study TR4’s physiological functions due to a lack of specific ligands. Gene knock-out animal techniques provide an alternative approach for defining the biological functions of TR4. In vivo studies of TR4 gene knockout mice (TR4−/−) found that they display severe spinal curvature, subfertility, premature aging, and prostate prostatic intraepithelial neoplasia (PIN) development. Upstream modulators, downstream target gene regulation, feedback mechanisms, and differential modulation mediated by the recruitment of other nuclear receptors and coregulators have been identified in studies using the TR4−/− phenotype. With the establishment of a tissue-specific TR4−/− mouse model, research on TR4 will be more convenient in the future.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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