CLC number: R944.9
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-09-24
Cited: 1
Clicked: 9987
Chun-yu Li, Zhe-wei Wang, Can Tu, Jia-bo Wang, Bing-qian Jiang, Qi Li, Ling-na Zeng, Zhi-jie Ma, Ping Zhang, Yan-ling Zhao, Ya-ming Zhang, Dan Yan, Rui Tan, Xiao-he Xiao. Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment[J]. Journal of Zhejiang University Science B, 2014, 15(10): 888-899.
@article{title="Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment",
author="Chun-yu Li, Zhe-wei Wang, Can Tu, Jia-bo Wang, Bing-qian Jiang, Qi Li, Ling-na Zeng, Zhi-jie Ma, Ping Zhang, Yan-ling Zhao, Ya-ming Zhang, Dan Yan, Rui Tan, Xiao-he Xiao",
journal="Journal of Zhejiang University Science B",
volume="15",
number="10",
pages="888-899",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400065"
}
%0 Journal Article
%T Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment
%A Chun-yu Li
%A Zhe-wei Wang
%A Can Tu
%A Jia-bo Wang
%A Bing-qian Jiang
%A Qi Li
%A Ling-na Zeng
%A Zhi-jie Ma
%A Ping Zhang
%A Yan-ling Zhao
%A Ya-ming Zhang
%A Dan Yan
%A Rui Tan
%A Xiao-he Xiao
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 10
%P 888-899
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400065
TY - JOUR
T1 - Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment
A1 - Chun-yu Li
A1 - Zhe-wei Wang
A1 - Can Tu
A1 - Jia-bo Wang
A1 - Bing-qian Jiang
A1 - Qi Li
A1 - Ling-na Zeng
A1 - Zhi-jie Ma
A1 - Ping Zhang
A1 - Yan-ling Zhao
A1 - Ya-ming Zhang
A1 - Dan Yan
A1 - Rui Tan
A1 - Xiao-he Xiao
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 10
SP - 888
EP - 899
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400065
Abstract: insulin is widely used in treating diabetes, but still needs to be administered by needle injection. This study investigated a new needle-free approach for insulin delivery. A portable powder needleless injection (PNI) device with an automatic mechanical unit was designed. Its efficiency in delivering insulin was evaluated in alloxan-induced diabetic rabbits. The skin irritation caused by the device was investigated and the results were analyzed in relation to aerodynamic parameters. Inorganic salt-carried insulin powders had hypoglycemic effects, while raw insulin powders were not effective when delivered by PNI, indicating that salt carriers play an important role in the delivery of insulin via PNI. The relative delivery efficiency of phosphate-carried insulin powder using the PNI device was 72.25%. A safety assessment test showed that three key factors (gas pressure, cylinder volume, and nozzle distance) were related to the amount of skin irritation caused by the PNI device. Optimized injection conditions caused minimal skin lesions and are safe to use in practice. The results suggest that PNI has promising prospects as a novel technology for delivering insulin and other biological drugs.
Open peer comments: Debate/Discuss/Question/Opinion
<1>
王子瑞<1016225253@qq.com>
2014-11-07 22:04:30
I am doing something related to this,so want to download and make a consideration