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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.6 P.598-600

http://doi.org/10.1631/jzus.B1400078


Hypocalcemia: a reversible cause of T wave alternans and heart failure


Author(s):  Yi-chen Yang1, Fa-rong Shen1, Yuan-qiang Lu2

Affiliation(s):  1. Department of Clinical Medicine, Graduate School, Zhejiang Chinese Medical University, Hangzhou 310053, China; more

Corresponding email(s):   yangyichenyz@126.com

Key Words:  Hypocalcemia, Heart failure, Arrhythmias, Cardiac, Hypoparathyroidism


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Yi-chen Yang, Fa-rong Shen, Yuan-qiang Lu. Hypocalcemia: a reversible cause of T wave alternans and heart failure[J]. Journal of Zhejiang University Science B, 2014, 15(6): 598-600.

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Abstract: 
We have read with great interest the recent article “Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem” by Zang and Xia (2014), published in Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). The authors proposed that both calcium handling and electrical components of cardiac cells could be the cellular mechanism of cardiac alternans, and identifying the main mechanism of cardiac alternans could help to cure targeted patients with heart failure. Here, we present a particular case, which may help you to understand our viewpoint.

低钙血症:T波电交替和心衰的一个可逆病因

本文概要:由于钙离子在心肌细胞兴奋-收缩偶联中发挥着核心作用,低钙血症可诱发心肌病。临床上,由于低钙血症导致的T波电交替和急性心衰罕见,极易被忽视或误诊。研究显示,低钙血症引起的T波电交替和急性心衰往往是可逆的,因而及时纠正严重低钙血症十分重要。本文报告一例慢性甲状旁腺功能减退症患者,由于严重的低钙血症引起T波电交替和急性心衰发作,在迅速纠正低钙血症后,患者病情得以缓解,T波电交替完全消失,心功能部分恢复。通过复习该病例,有助于临床医生重视可引起T波电交替和心衰的可逆性因素-低钙血症。
关键词:低钙血症;心力衰竭;心律失常;心性;甲状旁腺功能减退症

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References

[1] Aguiar, P., Cruz, D., Ferro Rodrigues, R., 2013. Hypocalcemic cardiomyopathy. Rev Port Cardiol, 32(4):331-335. 


[2] Catalano, A., Basile, G., Lasco, A., 2012. Hypocalcemia: a sometimes overlooked cause of heart failure in the elderly. Aging Clin Exp Res, 24(4):400-403. 


[3] Iwazu, Y., Muto, S., Ikeuchi, S., 2006. Reversible hypocalcemic heart failure with T wave alternans and increased QTc dispersion in a patient with chronic renal failure after parathyroidectomy. Clin Nephrol, 65(1):65-70. 


[4] Rhee, H.S., Lee, S.W., Jung, Y.K., 2013. Takotsubo cardiomyopathy associated with severe hypocalcemia secondary to idiopathic hypoparathyroidism. Korean Circ J, 43(8):573-577. 


[5] Zang, Y.L., Xia, L., 2014. Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 15(3):201-211. 



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