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CLC number: R285.5

On-line Access: 2015-07-03

Received: 2014-09-20

Revision Accepted: 2015-02-01

Crosschecked: 2015-06-16

Cited: 1

Clicked: 3197

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yue-min Ding

http://orcid.org/0000-0002-0763-9400

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.7 P.593-601

http://doi.org/10.1631/jzus.B1400249


Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia


Author(s):  Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, Yue-min Ding

Affiliation(s):  Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China

Corresponding email(s):   dingyuemin@zucc.edu.cn

Key Words:  Bamboo leaf extract, Dementia, Alzheimer’, s disease, Neurotransmitter


Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, Yue-min Ding. Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia[J]. Journal of Zhejiang University Science B, 2015, 16(7): 593-601.

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author="Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, Yue-min Ding",
journal="Journal of Zhejiang University Science B",
volume="16",
number="7",
pages="593-601",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400249"
}

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%T Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia
%A Jian-xiang Liu
%A Min-ying Zhu
%A Ci-yuan Feng
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%A Ying Zhan
%A Zhan Zhao
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%DOI 10.1631/jzus.B1400249

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A1 - Ying Zhan
A1 - Zhan Zhao
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DOI - 10.1631/jzus.B1400249


Abstract: 
Senile dementia (SD) is a syndrome characterized by progressive neurological deterioration. Treatment for the disease is still under investigation. bamboo leaf extract (B-extract) has been known for its biological efficacy in anti-oxidant and anti-cancer activities. However, study on B-extract for its protection against dementia is very limited. The effect of B-extract on a rat model with SD was examined. B-extract improved spatial learning ability of the dementia rats. The hippocampus of dementia model rats showed reduced levels of acetylcholine (ACh), epinephrine (E), norepinephrine (NE), and dopamine (DA), and increased activities of acetylcholine esterase (AChE) and monoamine oxidase (MAO). Treatment with B-extract 20 mg/(kg·d) for 7 weeks significantly inhibited the enzyme activity compared with untreated dementia rats, and raised the levels of ACh, E, and DA in the hippocampus. In addition, treatment with B-extract elevated the level of γ-aminobutyric acid (GABA), but reduced the level of glutamate (Glu) in the brain. These data suggest that B-extract might be a potential drug in treating impairment of spatial memory in dementia rats by regulating the central neurotransmitter function.

竹叶提取物改善老年痴呆模型大鼠的空间学习能力

目的:竹叶提取物在抗氧化和抗肿瘤方面的生物学效应已经为人所知,但是它是否能防治痴呆还未见研究报道。本课题旨在研究竹叶提取物对老年痴呆大鼠的空间学习能力的影响及其可能机制。
创新点:本研究首次提出竹叶提取物能显著改善老年痴呆大鼠的空间学习能力,它能通过抑制胆碱酯酶和单胺氧化酶的活性来增加海马组织乙酰胆碱和单胺类递质的含量,并且调控谷氨酸和γ-氨基丁酸的含量,从而正面影响老年痴呆大鼠的神经功能。
方法:采用每日腹腔注射D-半乳糖(60mg/kg),6周末于侧脑室注射β-淀粉样物(Aβ)l-42(10µg)的方法制造老年痴呆大鼠模型。治疗组大鼠在造模过程中连续7周每日喂饲竹叶提取物(20mg/kg)。7周末用Morris水迷宫进行为期5天的定位航行试验,结束后取海马和皮质脑组织,用酶联免疫吸附测定法(ELISA)测定乙酰胆碱、单胺类递质、5-羟色胺、谷氨酸和γ-氨基丁酸含量及相关酶活性。
结论:竹叶提取物可能在改善老年痴呆大鼠空间记忆能力方面有潜在治疗价值,其作用可能通过调控脑内神经递质功能得以实现。

关键词:竹叶提取物;痴呆;阿尔茨海默病;神经递质

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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