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CLC number: R571

On-line Access: 2020-07-07

Received: 2019-08-16

Revision Accepted: 2019-12-15

Crosschecked: 2020-06-05

Cited: 0

Clicked: 1934

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yuan-yuan Nian

https://orcid.org/0000-0002-0989-9417

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.7 P.581-589

http://doi.org/10.1631/jzus.B1900498


Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus


Author(s):  Yuan-yuan Nian, Xian-mei Meng, Jing Wu, Fu-chu Jing, Xue-qin Wang, Tong Dang, Jun Zhang

Affiliation(s):  Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou 014040, China; more

Corresponding email(s):   mxmxhk@163.com, jun3z@163.com

Key Words:  Short-segment Barrett’, s esophagus, Postprandial proximal gastric acid pocket (PPGAP), Gastroesophageal acid reflux


Yuan-yuan Nian, Xian-mei Meng, Jing Wu, Fu-chu Jing, Xue-qin Wang, Tong Dang, Jun Zhang. Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus[J]. Journal of Zhejiang University Science B, 2020, 21(7): 581-589.

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author="Yuan-yuan Nian, Xian-mei Meng, Jing Wu, Fu-chu Jing, Xue-qin Wang, Tong Dang, Jun Zhang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="7",
pages="581-589",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900498"
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%0 Journal Article
%T Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus
%A Yuan-yuan Nian
%A Xian-mei Meng
%A Jing Wu
%A Fu-chu Jing
%A Xue-qin Wang
%A Tong Dang
%A Jun Zhang
%J Journal of Zhejiang University SCIENCE B
%V 21
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%P 581-589
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900498

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T1 - Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus
A1 - Yuan-yuan Nian
A1 - Xian-mei Meng
A1 - Jing Wu
A1 - Fu-chu Jing
A1 - Xue-qin Wang
A1 - Tong Dang
A1 - Jun Zhang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 7
SP - 581
EP - 589
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900498


Abstract: 
Objective: To determine the characteristics of postprandial proximal gastric acid pockets (PPGAPs) and their association with gastroesophageal acid reflux in patients with Barrett’s esophagus (BE). Methods: Fifteen patients with BE (defined by columnar lined esophagus of ≥1 cm) and 15 healthy individuals that were matched for age, gender, and body mass index, were recruited. The fasting intragastric pH and the appearance time, length, lowest pH, and mean pH of the PPGAP were determined using a single pH electrode pull-through experiment. For BE patients, a gastroesophageal reflux disease questionnaire (GerdQ) was completed and esophageal 24-h pH monitoring was carried out. Results: The PPGAP was significantly longer (5 (3, 5) cm vs. 2 (1, 2) cm) and the lowest pH (1.1 (0.8, 1.5) vs. 1.6 (1.4, 1.9)) was significantly lower in patients with short-segment BE than in healthy individuals. The PPGAP started to appear proximally from the gastroesophageal pH step-up point to the esophageal lumen. The acidity of the PPGAP was higher in the distal segment than in the proximal segment. In short-segment BE patients, there were significant correlations between the acidity and the appearance time and length of the PPGAP. The length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux episodes. The acidity of the PPGAP was associated with the DeMeester scores, the GerdQ scores, and the fasting intragastric pH. Conclusions: In patients with short-segment BE, a PPGAP is commonly seen. Its length and acidity of PPGAP are associated with gastroesophageal acid reflux, the DeMeester score, and the GerdQ score in patients with short-segment BE.

短节段Barrett’s食管的胃食管酸反流与餐后近端胃酸袋的相关性研究

目的:检测并分析短节段Barrett’s食管(BE)患者的餐后近端胃酸袋(PPGAP)的特点,并分析其与胃食管酸反流的相关性.
创新点:PPGAP可能是胃食管反流病的病理因素之一,引起广泛关注,而BE患者的PPGAP特点及与反流的相关性尚无报道.
方法:15名短节段BE患者和15名健康志愿者分别以牵拉法检测PPGAP的发生时间、长度、最低pH值和平均pH值.BE患者完成GerdQ问卷调查和24 h食管pH监测.
结论:短节段BE患者普遍存在PPGAP,同时PPGAP的长度和酸度与其胃食管酸反流周期数、DeMeester评分和GerdQ评分具有相关性.

关键词:短节段Barrett’s食管;餐后近端胃酸袋(PPGAP);胃食管酸反流

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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