Full Text:   <1613>

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CLC number: R714.21

On-line Access: 2016-03-07

Received: 2015-07-25

Revision Accepted: 2015-12-03

Crosschecked: 2016-02-15

Cited: 0

Clicked: 3130

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jing Du

http://orcid.org/0000-0002-6767-2763

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.3 P.218-224

http://doi.org/10.1631/jzus.B1500180


Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss


Author(s):  Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan

Affiliation(s):  Shanghai Obstetrics/Gynecology Hospital, Fudan University, Shanghai 200011, China; more

Corresponding email(s):   dujing42@126.com, yuanwei11@yahoo.com

Key Words:  Prokineticin receptor 1 (PKR1), PKR2, Polymorphism, Recurrent pregnancy loss


Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss[J]. Journal of Zhejiang University Science B, 2016, 17(3): 218-224.

@article{title="Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss",
author="Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="218-224",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500180"
}

%0 Journal Article
%T Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
%A Yun-lei Cao
%A Zhao-feng Zhang
%A Jian Wang
%A Mao-hua Miao
%A Jian-hua Xu
%A Yue-ping Shen
%A Ai-min Chen
%A Jing Du
%A Wei Yuan
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 218-224
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500180

TY - JOUR
T1 - Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
A1 - Yun-lei Cao
A1 - Zhao-feng Zhang
A1 - Jian Wang
A1 - Mao-hua Miao
A1 - Jian-hua Xu
A1 - Yue-ping Shen
A1 - Ai-min Chen
A1 - Jing Du
A1 - Wei Yuan
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 218
EP - 224
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500180


Abstract: 
recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.

前动力蛋白受体(PKR1 rs4627609 和 PKR2 rs6053283)的多态性与复发性流产的关系

目的:研究前动力蛋白受体PKR1 rs4627609和PKR2 rs6053283的多态性与复发性流产的关系,并对其可能的作用机制进行预测。
创新点:首次在中国汉族人群中进行前动力蛋白受体PKR1 rs4627609和PKR2 rs6053283的多态性与复发性流产关系的研究,并对其功能进行预测。
方法:共收集了93例复发性流产和169例健康对照者血液样本,提取基因组DNA,对PKR1 rs4627609和PKR2 rs6053283两个位点进行基因多态性分析,在两组样本中分析不同基因型与复发性流产的关系,并对PKR2 rs6053283位点的不同等位基因进行生物功能预测。
结论:PKR2 rs6053283的多态性与复发性流产相关;而PKR1 rs4627609的多态性与复发性流产之间不存在相关性。

关键词:前动力蛋白受体1;前动力蛋白受体2;多态性;复发性流产

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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