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On-line Access: 2016-10-02

Received: 2015-08-13

Revision Accepted: 2016-02-17

Crosschecked: 2016-09-11

Cited: 3

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Citations:  Bibtex RefMan EndNote GB/T7714


Hong-nan Liu


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.10 P.752-762


Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets

Author(s):  Huan-sheng Yang, Fei Wu, Li-na Long, Tie-jun Li, Xia Xiong, Peng Liao, Hong-nan Liu, Yu-long Yin

Affiliation(s):  Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture; more

Corresponding email(s):   xx@isa.ac.cn, liuhn@isa.ac.cn

Key Words:  Yeast products, Weaned piglet, Intestinal morphology, Barrier function, Antioxidant system

Huan-sheng Yang, Fei Wu, Li-na Long, Tie-jun Li, Xia Xiong, Peng Liao, Hong-nan Liu, Yu-long Yin. Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets[J]. Journal of Zhejiang University Science B, 2016, 17(10): 752-762.

@article{title="Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets",
author="Huan-sheng Yang, Fei Wu, Li-na Long, Tie-jun Li, Xia Xiong, Peng Liao, Hong-nan Liu, Yu-long Yin",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets
%A Huan-sheng Yang
%A Fei Wu
%A Li-na Long
%A Tie-jun Li
%A Xia Xiong
%A Peng Liao
%A Hong-nan Liu
%A Yu-long Yin
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 10
%P 752-762
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500192

T1 - Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets
A1 - Huan-sheng Yang
A1 - Fei Wu
A1 - Li-na Long
A1 - Tie-jun Li
A1 - Xia Xiong
A1 - Peng Liao
A1 - Hong-nan Liu
A1 - Yu-long Yin
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 10
SP - 752
EP - 762
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500192

The goal of this study was to evaluate the effects of a mixture of yeast culture, cell wall hydrolysates, and yeast extracts (collectively “yeast products,” YP) on the performance, intestinal physiology, and health of weaned piglets. A total of 90 piglets weaned at 21 d of age were blocked by body weight, sex, and litter and randomly assigned to one of three treatments for a 14-d feeding experiment, including (1) a basal diet (control), (2) 1.2 g/kg of YP, and (3) 20 mg/kg of colistin sulfate (CSE). No statistically significant differences were observed in average daily feed intake, average daily weight gain, or gain-to-feed ratio among CSE, YP, and control piglets. Increased prevalence of diarrhea was observed among piglets fed the YP diet, whereas diarrhea was less prevalent among those fed CSE. Duodenal and jejunal villus height and duodenal crypt depth were greater in the control group than they were in the YP or CSE groups. Intraepithelial lymphocytes (IEL) in the duodenal and jejunal villi were enhanced by YP, whereas IEL in the ileal villi were reduced in weaned piglets fed YP. Secretion of jejunal and ileal interleukin-10 (IL-10) was higher and intestinal and serum antioxidant indexes were affected by YP and CSE. In YP- and CSE-supplemented animals, serum D-lactate concentration and diamine oxidase (DAO) activity were both increased, and intestinal mRNA expressions of occludin and ZO-1 were reduced as compared to the control animals. In conclusion, YP supplementation in the diets of weaned piglets appears to increase the incidence of diarrhea and has adverse effects on intestinal morphology and barrier function.


方法:90头21日龄断奶仔猪随机分为3组,分别饲喂基础日粮(对照组),含1.2 g/kg的酵母混合物(YP组)及含20 mg/kg硫酸粘杆菌素日粮(CSE组)14天,比较三组间各项指标差异。
结论:结果表明,三组之间平均日采食量、平均日增重和料肉比无显著差异。YP组腹泻发生率显著高于其它两组。对照组十二指肠和空肠的绒毛高度以及十二指肠的隐窝深度显著高于YP组和CSE组。相对于对照组或CSE组,YP组十二指肠和空肠绒毛淋巴细胞数目显著增加,而回肠绒毛内淋巴细胞数目显著降低。相对于对照组,YP组空肠和回肠内白介素-10(IL-10)的分泌增加,YP和CSE也显著影响了仔猪肠道和血清中抗氧化因子;YP和CSE组血清d-乳酸浓度和二胺氧化酶活性都增强;YP组或CSE组肠道occludinZO-1 mRNA表达降低。综上所述,酵母混合物添加会增加断奶仔猪腹泻发生率,并对断奶仔猪肠道形态学和屏障功能具有副作用。


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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