CLC number: S816.3
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-12-05
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Yang Wang, Li Gong, Yan-ping Wu, Zhi-wen Cui, Yong-qiang Wang, Yi Huang, Xiao-ping Zhang, Wei-fen Li. Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets[J]. Journal of Zhejiang University Science B, 2019, 20(2): 180-192.
@article{title="Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets",
author="Yang Wang, Li Gong, Yan-ping Wu, Zhi-wen Cui, Yong-qiang Wang, Yi Huang, Xiao-ping Zhang, Wei-fen Li",
journal="Journal of Zhejiang University Science B",
volume="20",
number="2",
pages="180-192",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800022"
}
%0 Journal Article
%T Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets
%A Yang Wang
%A Li Gong
%A Yan-ping Wu
%A Zhi-wen Cui
%A Yong-qiang Wang
%A Yi Huang
%A Xiao-ping Zhang
%A Wei-fen Li
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 2
%P 180-192
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800022
TY - JOUR
T1 - Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets
A1 - Yang Wang
A1 - Li Gong
A1 - Yan-ping Wu
A1 - Zhi-wen Cui
A1 - Yong-qiang Wang
A1 - Yi Huang
A1 - Xiao-ping Zhang
A1 - Wei-fen Li
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 2
SP - 180
EP - 192
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800022
Abstract: To understand the effects of Lactobacillus rhamnosus GG (ATCC 53103) on intestinal barrier function in pre-weaning piglets under normal conditions, twenty-four newborn littermate piglets were randomly divided into two groups. piglets in the control group were orally administered with 2 mL 0.1 g/mL sterilized skim milk while the treatment group was administered the same volume of sterilized skim milk with the addition of viable L. rhamnosus at the 1st, 3rd, and 5th days after birth. The feeding trial was conducted for 25 d. Results showed that piglets in the L. rhamnosus group exhibited increased weaning weight and average daily weight gain, whereas diarrhea incidence was decreased. The bacterial abundance and composition of cecal contents, especially Firmicutes, Bacteroidetes, and Fusobacteria, were altered by probiotic treatment. In addition, L. rhamnosus increased the jejunal permeability and promoted the immunologic barrier through regulating antimicrobial peptides, cytokines, and chemokines via Toll-like receptors. Our findings indicate that oral administration of L. rhamnosus GG to newborn piglets is beneficial for intestinal health of pre-weaning piglets by improving the biological, physical, and immunologic barriers of intestinal mucosa.
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[87]List of electronic supplementary materials
[88]Table S1 Composition of sows’ diet
[89]Table S2 Nutrient levels of sows’ diet
[90]Table S3 Composition of pre-starter feed
[91]Table S4 Nutrient levels of pre-starter feed
[92]Fig. S1 Experimental protocol design
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