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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.4 P.341-350


Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats

Author(s):  Joshua J. MALAGO, Hortensia NONDOLI

Affiliation(s):  Department of Pathology, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3203, Morogoro, Tanzania; more

Corresponding email(s):   malagojj@yahoo.com, jmalago@suanet.ac.tz

Key Words:  Ulcerative colitis, Dextran sulfate sodium, Sodium arsenite, Rats

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Joshua J. MALAGO, Hortensia NONDOLI. Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats[J]. Journal of Zhejiang University Science B, 2008, 9(4): 341-350.

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author="Joshua J. MALAGO, Hortensia NONDOLI",
journal="Journal of Zhejiang University Science B",
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%T Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats
%A Joshua J. MALAGO
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%P 341-350
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0720198

T1 - Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats
A1 - Joshua J. MALAGO
A1 - Hortensia NONDOLI
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 4
SP - 341
EP - 350
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0720198

The histopathological features and the associated clinical findings of ulcerative colitis (UC) are due to persistent inflammatory response in the colon mucosa. Interventions that suppress this response benefit UC patients. We tested whether sodium arsenite (SA) benefits rats with dextran sulfate sodium (DSS)-colitis. The DSS-colitis was induced by 5% DSS in drinking water. SA (10 mg/kg; intraperitoneally) was given 8 h before DSS treatment and then every 48 h for 3 cycles of 7, 14 or 21 d. At the end of each cycle rats were sacrificed and colon sections processed for histological examination. DSS induced diarrhea, loose stools, hemoccult positive stools, gross bleeding, loss of body weight, loss of epithelium, crypt damage, depletion of goblet cells and infiltration of inflammatory cells. The severity of these changes increased in the order of Cycles 1, 2 and 3. Treatment of rats with SA significantly reduced this severity and improved the weight gain.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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