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CLC number: R246.3

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2018-10-26

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Fan Qu

https://orcid.org/0000-0003-1851-1514

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.11 P.815-817

http://doi.org/10.1631/jzus.B1801014


Towards a multidimensional scientific approach to improve clinical practices for infertility treatment


Author(s):  Yu-hang Zhu, Fan Qu

Affiliation(s):  Womens Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China 2Institute for Womens Health, University College London, London NW3 2PF, the United Kingdom

Corresponding email(s):   syqufan@zju.edu.cn

Key Words:  Multidimensional, Infertility treatment, Clinical practices


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Yu-hang Zhu, Fan Qu. Towards a multidimensional scientific approach to improve clinical practices for infertility treatment[J]. Journal of Zhejiang University Science B, 2018, 19(11): 815-817.

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Abstract: 
Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder in women, leading to infertility. However, there is no general agreement concerning how to diagnose and treat PCOS. The Rotterdam consensus statement from the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine, the Chinese diagnostic criteria and consensus statement, and the clinical practice guideline from the Endocrine Society in the USA are widely recognized. Guidance has been provided for clinical practice based on a comparative analysis of the above three practice guidelines or consensus statements (Wang et al., 2018a). High body mass index (BMI) has no negative effect on the outcome of in vitro fertilization (IVF) in Chinese patients with PCOS; however, the conclusion may be limited by the retrospective design and potential bias (Pan et al., 2018). Neonatal birth weight is positively affected by both maternal pre-pregnancy body mass index (pre-BMI) and gestational weight gain (Du et al., 2017). Normal body weight is very important for conception. Women with PCOS are almost 3 times more likely to be obese than those without PCOS; however, no specific interventions are available to induce weight loss, and drugs are used to treat other symptoms of the syndrome or obesity in the general population. A network meta-analysis found that the amount of weight loss differed significantly according to the choice of drugs (in descending order):liraglutide, orlistat, and metformin. Liraglutide alone, liraglutide/metformin, and metformin alone significantly reduced waist circumference, but no change was found with orlistat, indicating liraglutide appears superior to the other drugs in reducing weight and waist circumference (Wang et al., 2018b). IVF, as a choice for more than 1 000 000 infertile couples each year, gives rise to the birth of over 3 000 000 babies worldwide.

通过多维度的科学方法提高不孕症治疗的临床实践水平

概要:不孕症正日渐成为一个重要的社会关切问题.中医及心理干预在不孕症的治疗,甚至提高子代健康水平等方面具有一定优势,但仍需更加规范及国际性的多中心临床研究来加强其有效临床治疗的循证基础.
关键词:多维度;不孕症;临床实践

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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