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CLC number: R730.231

On-line Access: 2017-05-04

Received: 2016-12-19

Revision Accepted: 2017-02-12

Crosschecked: 2017-04-19

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.5 P.365-372


DNA methylation in the tumor microenvironment

Author(s):  Meng-wen Zhang, Kenji Fujiwara, Xu Che, Shu Zheng, Lei Zheng

Affiliation(s):  The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   zhengshu@zju.edu.cn, lzheng6@jhmi.edu

Key Words:  Tumor microenvironment (TME), DNA methylation, Cancer-associated fibroblasts, Cancer-associated immune cells, Epigenetic therapy

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Meng-wen Zhang, Kenji Fujiwara, Xu Che, Shu Zheng, Lei Zheng. DNA methylation in the tumor microenvironment[J]. Journal of Zhejiang University Science B, 2017, 18(5): 365-372.

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%T DNA methylation in the tumor microenvironment
%A Meng-wen Zhang
%A Kenji Fujiwara
%A Xu Che
%A Shu Zheng
%A Lei Zheng
%J Journal of Zhejiang University SCIENCE B
%V 18
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600579

T1 - DNA methylation in the tumor microenvironment
A1 - Meng-wen Zhang
A1 - Kenji Fujiwara
A1 - Xu Che
A1 - Shu Zheng
A1 - Lei Zheng
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 5
SP - 365
EP - 372
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600579

The tumor microenvironment (TME) plays an important role in supporting cancer progression. The TME is composed of tumor cells, the surrounding tumor-associated stromal cells, and the extracellular matrix (ECM). Crosstalk between the TME components contributes to tumorigenesis. Recently, one of our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells can induce DNA methylation in cancer-associated fibroblasts (CAFs), thereby modifying tumor-stromal interactions in the TME, and subsequently creating a TME that supports tumor growth. Here we summarize recent studies about how DNA methylation affects tumorigenesis through regulating tumor-associated stromal components including fibroblasts and immune cells. We also discuss the potential for targeting DNA methylation for the treatment of cancers.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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