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On-line Access: 2021-11-16

Received: 2021-01-11

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 ORCID:

Helin FENG

https://orcid.org/0000-0002-7260-5485

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.11 P.885-892

http://doi.org/10.1631/jzus.B2100029


Tumor-associated macrophages in osteosarcoma


Author(s):  Yi ZHAO, Benzheng ZHANG, Qianqian ZHANG, Xiaowei MA, Helin FENG

Affiliation(s):  Department of Orthopedics, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; more

Corresponding email(s):   helinfeng0311@163.com

Key Words:  Tumor-associated macrophage, Osteosarcoma, Tumor microenvironment


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Yi ZHAO, Benzheng ZHANG, Qianqian ZHANG, Xiaowei MA, Helin FENG. Tumor-associated macrophages in osteosarcoma[J]. Journal of Zhejiang University Science B, 2021, 22(11): 885-892.

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Abstract: 
osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. It is an aggressive tumor with a tendency to spread to the lung, which is the most common site of metastasis. Patients with advanced OS with metastases have poor prognoses despite the application of chemotherapy, thus highlighting the need for novel therapeutic targets. The tumor microenvironment (TME) of OS is confirmed to be essential for and supportive of tumor growth and dissemination. The immune component of the OS microenvironment is mainly composed of tumor-associated macrophages (TAMs). In OS, TAMs promote tumor growth and angiogenesis and upregulate the cancer stem cell-like phenotype. However, TAMs inhibit the metastasis of OS. Therefore, much attention has been paid to investigating the mechanism of TAMs in OS development and the progression of immunotherapy for OS. In this article, we aim to summarize the roles of TAMs in OS and the major findings on the application of TAMs in OS treatment.

肿瘤相关巨噬细胞在骨肉瘤的研究进展

概要:骨肉瘤(Osteosarcoma,OS)是儿童和青少年最常见的原发性骨肿瘤。它是一种侵袭性很强的恶性肿瘤。晚期伴有转移的OS患者尽管应用了化疗,但预后仍较差,因此探寻新的治疗靶点成为了OS的研究热点。OS细胞的肿瘤微环境(Tumor microenvironment,TME)被证实是支持肿瘤生长和扩散的必要条件。OS微环境的免疫成分主要由肿瘤相关巨噬细胞(Tumor-associated macrophages,TAMs)组成。在OS中,TAMs促进肿瘤生长和血管生成,并上调肿瘤干细胞样表型。本文通过深入分析TAMs已有的研究成果,指出目前的研究状态,并系统总结了TAMs在OS发生发展及治疗的进展情况,提出自己的观点。我们发现,TAMs在促进OS生长和血管生成以及上调OS干细胞样表型中发挥重要作用,但OS微环境如何影响TAMs表型以及TAMs与OS之间的相互作用机制还需要补充研究和进一步实验。

关键词:肿瘤相关巨噬细胞;骨肉瘤;肿瘤微环境

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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