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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.8 P.628-636


Estrogen modulation of visceral pain

Author(s):  Li-Hong Sun, Wen-Xin Zhang, Qi Xu, Hui Wu, Cui-Cui Jiao, Xin-Zhong Chen

Affiliation(s):  Department of Anesthesiology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   chenxinz@zju.edu.cn

Key Words:  Estrogen, Visceral pain, Hyperalgesia, Ovariectomization

Li-Hong Sun, Wen-Xin Zhang, Qi Xu, Hui Wu, Cui-Cui Jiao, Xin-Zhong Chen. Estrogen modulation of visceral pain[J]. Journal of Zhejiang University Science B, 2019, 20(8): 628-636.

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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1800582

It is commonly accepted that females and males differ in their experience of pain. Gender differences have been found in the prevalence and severity of pain in both clinical and animal studies. Sex-related hormones are found to be involved in pain transmission and have critical effects on visceral pain sensitivity. Studies have pointed out the idea that serum estrogen is closely related to visceral nociceptive sensitivity. This review aims to summarize the literature relating to the role of estrogen in modulating visceral pain with emphasis on deciphering the potential central and peripheral mechanisms.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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