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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.1 P.3-11

http://doi.org/10.1631/jzus.B1800633


Lymphatic vasculature in tumor metastasis and immunobiology


Author(s):  Xinguo Jiang

Affiliation(s):  VA Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA

Corresponding email(s):   xinguoj@stanford.edu

Key Words:  Lymphatic, Lymphatic endothelial cell (LEC), Cancer, Metastasis, Immunotherapy


Xinguo Jiang. Lymphatic vasculature in tumor metastasis and immunobiology[J]. Journal of Zhejiang University Science B, 2020, 21(1): 3-11.

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author="Xinguo Jiang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="1",
pages="3-11",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800633"
}

%0 Journal Article
%T Lymphatic vasculature in tumor metastasis and immunobiology
%A Xinguo Jiang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 1
%P 3-11
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800633

TY - JOUR
T1 - Lymphatic vasculature in tumor metastasis and immunobiology
A1 - Xinguo Jiang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 1
SP - 3
EP - 11
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800633


Abstract: 
lymphatic vessels are essential for tissue fluid homeostasis, immune cell trafficking, and intestinal lipid absorption. The lymphatics have long been recognized to serve as conduits for distant tumor dissemination. However, recent findings suggest that the regional lymphatic vasculature also shapes the immune microenvironment of the tumor mass and potentiates immunotherapy. This review discusses the role of lymphatic vessels in tumor metastasis and tumor immunity.

淋巴血管在肿瘤转移和免疫生物学中的作用

概要:淋巴系统被认为是肿瘤转移的重要途径之一,所以通常情况下肿瘤引起的淋巴血管增生会降低肿瘤预后,治疗上也建议淋巴清扫.但是最新的研究显示,淋巴系统可能对肿瘤免疫治疗有促进作用.这篇综述的主要目的是对相关领域做一个简短总结,以期待将来有更多的研究来关注淋巴系统对肿瘤治疗的影响.文章首先介绍肿瘤淋巴血管增生和淋巴转移的分子机制,然后介绍淋巴系统在肿瘤免疫中的作用,最后利用最新研究来证明淋巴系统有增强肿瘤免疫治疗的作用.
关键词:淋巴系统;淋巴内皮细胞;肿瘤;转移;免疫治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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