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Caiping REN


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.7 P.541-556


Roles of THEM4 in the Akt pathway: a double-edged sword

Author(s):  Wen XIE, Weidong LIU, Lei WANG, Bin ZHU, Cong ZHAO, Ziling LIAO, Yihan LI, Xingjun JIANG, Jie LIU, Caiping REN

Affiliation(s):  NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China; more

Corresponding email(s):   rencaiping@csu.edu.cn, braindream@163.com

Key Words:  Protein kinase B (Akt), Thioesterase superfamily member 4 (THEM4), Tumor proliferation, Tumor metastasis

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Wen XIE, Weidong LIU, Lei WANG, Bin ZHU, Cong ZHAO, Ziling LIAO, Yihan LI, Xingjun JIANG, Jie LIU, Caiping REN. Roles of THEM4 in the Akt pathway: a double-edged sword[J]. Journal of Zhejiang University Science B, 2024, 25(7): 541-556.

@article{title="Roles of THEM4 in the Akt pathway: a double-edged sword",
author="Wen XIE, Weidong LIU, Lei WANG, Bin ZHU, Cong ZHAO, Ziling LIAO, Yihan LI, Xingjun JIANG, Jie LIU, Caiping REN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Roles of THEM4 in the Akt pathway: a double-edged sword
%A Wen XIE
%A Weidong LIU
%A Bin ZHU
%A Cong ZHAO
%A Ziling LIAO
%A Yihan LI
%A Xingjun JIANG
%A Jie LIU
%A Caiping REN
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 7
%P 541-556
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300457

T1 - Roles of THEM4 in the Akt pathway: a double-edged sword
A1 - Wen XIE
A1 - Weidong LIU
A1 - Lei WANG
A1 - Bin ZHU
A1 - Cong ZHAO
A1 - Ziling LIAO
A1 - Yihan LI
A1 - Xingjun JIANG
A1 - Jie LIU
A1 - Caiping REN
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 7
SP - 541
EP - 556
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300457

The protein kinase B (Akt) pathway can regulate the growth, proliferation, and metabolism of tumor cells and stem cells through the activation of multiple downstream target genes, thus affecting the development and treatment of a range of diseases. thioesterase superfamily member 4 (THEM4), a member of the thioesterase superfamily, is one of the Akt kinase-binding proteins. Some studies on the mechanism of cancers and other diseases have shown that THEM4 binds to Akt to regulate its phosphorylation. Initially, THEM4 was considered an endogenous inhibitor of Akt, which can inhibit the phosphorylation of Akt in diseases such as lung cancer, pancreatic cancer, and liver cancer, but subsequently, THEM4 was shown to promote the proliferation of tumor cells by positively regulating Akt activity in breast cancer and nasopharyngeal carcinoma, which contradicts previous findings. Considering these two distinct views, this review summarizes the important roles of THEM4 in the Akt pathway, focusing on THEM4 as an Akt-binding protein and its regulatory relationship with Akt phosphorylation in various diseases, especially cancer. This work provides a better understanding of the roles of THEM4 combined with Akt in the treatment of diseases.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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