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CLC number: R318.08
On-line Access: 2019-10-09
Received: 2019-09-04
Revision Accepted: 2019-09-11
Crosschecked: 2019-09-12
Cited: 0
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Automated microfluidic chip system for radiosynthesis of PET imaging probes
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Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang. Automated microfluidic chip system for radiosynthesis of PET imaging probes[J]. Journal of Zhejiang University Science B, 2019, 20(11): 865-867.
@article{title="Automated microfluidic chip system for radiosynthesis of PET imaging probes",
author="Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang",
journal="Journal of Zhejiang University Science B",
volume="20",
number="11",
pages="865-867",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900535"
}
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%I Zhejiang University Press & Springer
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A1 - Jian-zhang Pan
A1 - Guang-ming Xu
A1 - Pei-zhen Du
A1 - Mei Tian
A1 - Hong Zhang
J0 - Journal of Zhejiang University Science B
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Abstract: positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and “real-time” monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008). The development of molecular probes bearing short-lived positron-emitting radionuclides, such as 18F (half-life 110 min) or 11C (half-life 20 min), is crucial for PET imaging to collect in vivo metabolic information in a time-efficient manner (Deng et al., 2019). In this regard, one of the main challenges is rapid synthesis of radiolabeled probes by introducing the radionuclides into pharmaceuticals as soon as possible before injection for a PET scan. Although many potential PET probes have been discovered, only a handful can satisfy the demand for a highly efficient synthesis procedure that achieves radiolabeling and delivery for imaging within 1–2 radioisotope half-lives. Only a few probes, such as 2-deoxy-2-[18F]fluoro-
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