CLC number: R94; TB383
On-line Access: 2020-07-07
Received: 2019-12-08
Revision Accepted: 2020-03-20
Crosschecked: 2020-06-05
Cited: 0
Clicked: 3796
Xiao Liu, Hai Liu, Su-lan Wang, Jing-wen Liu. Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy[J]. Journal of Zhejiang University Science B, 2020, 21(7): 571-580.
@article{title="Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy",
author="Xiao Liu, Hai Liu, Su-lan Wang, Jing-wen Liu",
journal="Journal of Zhejiang University Science B",
volume="21",
number="7",
pages="571-580",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900624"
}
%0 Journal Article
%T Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy
%A Xiao Liu
%A Hai Liu
%A Su-lan Wang
%A Jing-wen Liu
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 7
%P 571-580
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900624
TY - JOUR
T1 - Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy
A1 - Xiao Liu
A1 - Hai Liu
A1 - Su-lan Wang
A1 - Jing-wen Liu
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 7
SP - 571
EP - 580
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900624
Abstract: To reduce the problems of poor solubility, high in vivo dosage requirement, and weak targeting ability of paclitaxel (PTX), a hyaluronic acid-octadecylamine (HA-ODA)-modified nano-structured lipid carrier (HA-NLC) was constructed. HA-ODA conjugates were synthesized by an amide reaction between HA and ODA. The hydrophobic chain of HA-ODA can be embedded in the lipid core of the NLC to obtain HA-NLC. The HA-NLC displayed strong internalization in cluster determinant 44 (CD44) highly expressed MCF-7 cells, and endocytosis mediated by the CD44 receptor was involved. The HA-NLC had an encapsulation efficiency of PTX of 72.0%. The cytotoxicity of the PTX-loaded nanoparticle HA-NLC/PTX in MCF-7 cells was much stronger than that of the commercial preparation Taxol®. In vivo, the HA-NLC exhibited strong tumor targeting ability. The distribution of the NLCs to the liver and spleen was reduced after HA modification, while more nanoparticles were aggregated to the tumor site. Our results suggest that HA-NLC has excellent properties as a nano drug carrier and potential for in vivo targeting.
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[29]List of electronic supplementary materials
[30]Fig. S1 Zeta potential determination of the nanoparticles (NLC, NLC/PTX, HA-NLC, and HA-NLC/PTX)
[31]Fig. S2 Size distribution of the nanoparticles (NLC, NLC/PTX, HA-NLC, and HA-NLC/PTX) at the 10th day after they were prepared
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