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CLC number: R512.6+2; R943; R978.7

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Received: 2008-02-16

Revision Accepted: 2008-04-24

Crosschecked: 0000-00-00

Cited: 9

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.6 P.506-510

http://doi.org/10.1631/jzus.B0820047


Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy


Author(s):  Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU

Affiliation(s):  Department of Pharmacy, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   xgzhang666@yahoo.com.cn

Key Words:  Adefovir dipivoxil (ADV), Solid lipid nanoparticles (SLN), Octadecylamine-fluorescein isothiocynate (ODA-FITC), Hepatitis B virus (HBV)


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Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy[J]. Journal of Zhejiang University Science B, 2008, 9(6): 506-510.

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author="Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU",
journal="Journal of Zhejiang University Science B",
volume="9",
number="6",
pages="506-510",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820047"
}

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%A Xing-guo ZHANG
%A Jing MIAO
%A Min-wei LI
%A Sai-ping JIANG
%A Fu-qiang HU
%A Yong-zhong DU
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%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820047

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T1 - Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
A1 - Xing-guo ZHANG
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A1 - Min-wei LI
A1 - Sai-ping JIANG
A1 - Fu-qiang HU
A1 - Yong-zhong DU
J0 - Journal of Zhejiang University Science B
VL - 9
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SP - 506
EP - 510
%@ 1673-1581
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PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820047


Abstract: 
Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15 wt% drug entrapment efficiency (EE) and 3 wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.

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Reference

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