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CLC number: R459.9

On-line Access: 2020-08-04

Received: 2019-11-04

Revision Accepted: 2020-02-19

Crosschecked: 2020-07-20

Cited: 0

Clicked: 1698

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xue-jun Sun

https://orcid.org/0000-0003-2387-5531

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.593-602

http://doi.org/10.1631/jzus.B1900629


Therapeutic effect of methane and its mechanism in disease treatment


Author(s):  Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun

Affiliation(s):  Department of Aviation and Diving Medicine, the Sixth Medical Center, General Hospital of People’s Liberation Army, Beijing 100048, China; more

Corresponding email(s):   sunxjk@126.com

Key Words:  Methane treatment, Ischemia and reperfusion injury, Inflammation, Methanogenesis


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Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun. Therapeutic effect of methane and its mechanism in disease treatment[J]. Journal of Zhejiang University Science B, 2020, 21(8): 593-602.

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author="Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun",
journal="Journal of Zhejiang University Science B",
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pages="593-602",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900629"
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%A Bradley P. Ander
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T1 - Therapeutic effect of methane and its mechanism in disease treatment
A1 - Zhou-heng Ye
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A1 - Bradley P. Ander
A1 - Xue-jun Sun
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900629


Abstract: 
Methane is the simplest hydrocarbon, consisting of one carbon atom and four hydrogen atoms. It is abundant in marsh gas, livestock rumination, and combustible ice. Little is known about the use of methane in human disease treatment. Current research indicates that methane is useful for treating several diseases including ischemia and reperfusion injury, and inflammatory diseases. The mechanisms underlying the protective effects of methane appear primarily to involve anti-oxidation, anti-inflammation, and anti-apoptosis. In this review, we describe the beneficial effects of methane on different diseases, summarize possible mechanisms by which methane may act in these conditions, and discuss the purpose of methane production in hypoxic conditions. Then we propose several promising directions for the future research.

甲烷治疗疾病效应及其机制

概要:甲烷是最简单的有机烃类,由1个碳原子和4个氢原子组成.甲烷在沼气、家畜反刍和可燃冰中含量丰富.甲烷在疾病治疗中的作用还未被大家熟悉.最近的研究表明甲烷可以治疗多种疾病,包括缺血再灌注损伤和炎症疾病.甲烷治疗疾病的机制可能包括抗氧化、抗炎症和抗凋亡.本文将描述甲烷对不同疾病的治疗效应,总结甲烷治疗效应的可能作用机制,并讨论甲烷在低氧环境下产生的目的.最后,我们也将提出甲烷研究的前景及探索方向.
关键词:甲烷治疗;缺血再灌注损伤;炎症;甲烷生成

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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