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Jianjun ZHANG


Zhongyang SHEN


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.6 P.451-470


Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook

Author(s):  Tao CHEN, Shipeng LI, Dewen DENG, Weiye ZHANG, Jianjun ZHANG, Zhongyang SHEN

Affiliation(s):  First Central Clinical School, Tianjin Medical University, Tianjin 300192, China; more

Corresponding email(s):   yzxzhangjianjun@163.com, zhongyangshen@vip.sina.com

Key Words:  Interferon regulatory factor (IRF-1), Hepatitis virus, Liver fibrosis, Hepatic ischemia-reperfusion injury (HIRI), Liver cancer

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Tao CHEN, Shipeng LI, Dewen DENG, Weiye ZHANG, Jianjun ZHANG, Zhongyang SHEN. Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook[J]. Journal of Zhejiang University Science B, 2024, 25(6): 451-470.

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author="Tao CHEN, Shipeng LI, Dewen DENG, Weiye ZHANG, Jianjun ZHANG, Zhongyang SHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook
%A Shipeng LI
%A Dewen DENG
%A Weiye ZHANG
%A Jianjun ZHANG
%A Zhongyang SHEN
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 6
%P 451-470
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300159

T1 - Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook
A1 - Tao CHEN
A1 - Shipeng LI
A1 - Dewen DENG
A1 - Weiye ZHANG
A1 - Jianjun ZHANG
A1 - Zhongyang SHEN
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 6
SP - 451
EP - 470
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300159

Interferon regulatory factor 1 (IRF-1) is a member of the IRF family. It is the first transcription factor to be identified that could bind to the interferon-stimulated response element (ISRE) on the target gene and displays crucial roles in the interferon-induced signals and pathways. IRF-1, as an important medium, has all of the advantages of full cell cycle regulation, cell death signaling transduction, and reinforcing immune surveillance, which are well documented. Current studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases, including but not limited to inhibiting the replication of the hepatitis virus (A/B/C/E), alleviating the progression of liver fibrosis, and aggravating hepatic ischemia-reperfusion injury (HIRI). The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients, which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer; additionally, the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease (AFLD/NAFLD), cholangiocarcinoma suppression, and uncommon traits in other liver diseases that had previously received little attention. Intriguingly, several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 signal. In this paper, we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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