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CLC number: R737.9

On-line Access: 2015-01-05

Received: 2014-07-03

Revision Accepted: 2014-12-02

Crosschecked: 2014-12-19

Cited: 25

Clicked: 6187

Citations:  Bibtex RefMan EndNote GB/T7714


Yun-ping LUO


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.18-31


MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential

Author(s):  Wei Wang, Yun-ping Luo

Affiliation(s):  Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

Corresponding email(s):   yunpingluo@hotmail.com

Key Words:  Breast cancer, MicroRNA, Oncogene, Tumor suppressors, Diagnosis marker, MicroRNA-based therapy

Wei Wang, Yun-ping Luo. MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential[J]. Journal of Zhejiang University Science B, 2015, 16(1): 18-31.

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DOI - 10.1631/jzus.B1400184

microRNAs (miRs) are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been observed in various types of cancer including breast cancer. Great efforts have been made to identify an association between microRNA expression profiles and breast cancer, and to understand the functional role and molecular mechanism of aberrant-expressed microRNAs. As research progressed, ‘oncogenic microRNAs’ and ‘tumor suppressive microRNAs’ became a focus of interest. The potential of candidate microRNAs from both intercellular (tissue) and extracellular (serum) sources for clinical diagnosis and prognosis was revealed, and treatments involving microRNA achieved some amazing curative effects in cancer disease models. In this review, advances from the most recent studies of microRNAs in one of the most common cancers, breast cancer, are highlighted, especially the functions of specifically selected microRNAs. We also assess the potential value of these microRNAs as diagnostic and prognostic markers, and discuss the possible development of microRNA-based therapies.

The topic of this review manuscript is very important as the microRNA is an emerging drug targets for cancer. The author also did a very good job collecting all the related information.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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Open peer comments: Debate/Discuss/Question/Opinion


Ava Kwong@The Univeristy of Hong Kong<avakwong@hku.hk>

2015-02-18 13:48:22

MicroRNAs play various role in the biological processes and cancer development. Vast numbers of miRNAs were found to be associated with breast cancer which maybe the potential target for therapeutic therapy to treat the disease. Our group has also been working on the diagnostic value of miRNAs in the ciculation of breast cancer patients. It would be important to delineate the cellular signaling pathway regulating the expression of these miRNAs in breast cancer for the development of targeted therapty against this disease.

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