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CLC number: R511
On-line Access: 2020-12-09
Received: 2020-04-17
Revision Accepted: 2020-10-22
Crosschecked: 2020-11-11
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Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China
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Yong-zheng Guo, Kai-jin Xu, Yong-tao Li, Jia-dan Fu, Min Xu, Ling Yu, Ji-fang Sheng, Biao Zhu. Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China[J]. Journal of Zhejiang University Science B, 2020, 21(12): 948-954.
@article{title="Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China",
author="Yong-zheng Guo, Kai-jin Xu, Yong-tao Li, Jia-dan Fu, Min Xu, Ling Yu, Ji-fang Sheng, Biao Zhu",
journal="Journal of Zhejiang University Science B",
volume="21",
number="12",
pages="948-954",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000204"
}
%0 Journal Article
%T Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China
%A Yong-zheng Guo
%A Kai-jin Xu
%A Yong-tao Li
%A Jia-dan Fu
%A Min Xu
%A Ling Yu
%A Ji-fang Sheng
%A Biao Zhu
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 12
%P 948-954
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000204
TY - JOUR
T1 - Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China
A1 - Yong-zheng Guo
A1 - Kai-jin Xu
A1 - Yong-tao Li
A1 - Jia-dan Fu
A1 - Min Xu
A1 - Ling Yu
A1 - Ji-fang Sheng
A1 - Biao Zhu
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 12
SP - 948
EP - 954
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000204
Abstract: The aim of this study was to evaluate the safety of an antiviral regimen of protease inhibitors combined with Arbidol (umifenovir) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia patients. The genomic sequence of SARS-CoV-2 is highly homologous to that of SARS-CoV (Zhou et al., 2020). Previously published basic and clinical research on anti-SARS-CoV treatment found that lopinavir/ritonavir (LPV/r) could improve the prognosis of SARS patients (Chan et al., 2003; Chu et al., 2004). darunavir (DRV) is another protease inhibitor that blocks the binding of SARS-CoV-2 to human angiotensin-converting enzyme 2 (Omotuyi et al., 2020). The broad-spectrum antiviral drug Arbidol (umifenovir) also shows in vitro anti-SARS-CoV activity (Khamitov et al., 2008).
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